{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:17:54Z","timestamp":1740176274180,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["World j. otorhinolaryngol.-head neck surg."],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to assess the relative efficacy of medications used following severe acute respiratory syndrome coronavirus\u20102 (SARS\u2010CoV\u20102) infection on self\u2010reported alterations in taste and\/or smell function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven hundred and fourteen persons with self\u2010reported postcoronavirus disease 2019 (post\u2010COVID\u201019) chemosensory disorders were personally interviewed regarding specific medications they were administered following the acute phase of the disease. The dependent measure\u2014self\u2010reported total recovery of chemosensory symptoms\u2014was subjected to stepwise logistic regression. Independent predictors included demographic and clinical variables, in addition to specific medications used to mitigate disease symptoms (i.e., systemic corticosteroids, oseltamivir, vitamin C, ibuprofen, hydroxychloroquine, azithromycin, ivermectin, nitazoxanide, anticoagulants, and zinc).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median time between COVID\u201019 symptom onset and the interviews was 81 days (interquartile range: 60\u2013104). Of the 714 subjects, 249 (34.9%) reported total recovery of their chemosensory function; 437 (61.2%) had at least one treatment since the beginning of the disease. Women and those with more comorbidities had undergone more treatments. The recovery rates of the treated and nontreated groups did not differ significantly. Nonetheless, respondents who had used nitazoxanide tended to have a higher rate of self\u2010reported taste or smell recovery. Those who took oral zinc were less likely to improve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No medication employed during the first months after SARS\u2010CoV\u20102 infection had a clear positive effect on returning self\u2010reported smell or taste function to normal, although nitrazoxide trended in a positive direction. Oral zinc had a negative effect on the reported recovery of these senses.<\/jats:p><\/jats:sec>","DOI":"10.1002\/wjo2.183","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T09:54:21Z","timestamp":1715594061000},"page":"88-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of drug therapies on self\u2010reported chemosensory outcomes after COVID\u201019"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5213-2337","authenticated-orcid":false,"given":"Marco A.","family":"Fornazieri","sequence":"first","affiliation":[{"name":"Department of Surgery Londrina State University Londrina Brazil"},{"name":"Department of Medicine Pontifical Catholic University of Paran\u00e1 Londrina Brazil"},{"name":"Department of Otorhinolaryngology University of S\u00e3o Paulo Sao Paulo Brazil"},{"name":"Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, Smell and Taste Center University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno M.","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Surgery Londrina State University Londrina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel P.","family":"Nic\u00e1cio","sequence":"additional","affiliation":[{"name":"Department of Surgery Londrina State University Londrina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas K.","family":"Anzolin","sequence":"additional","affiliation":[{"name":"Department of Surgery Londrina State University Londrina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 L. B.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Surgery Londrina State University Londrina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aristides Fernandes","family":"Neto","sequence":"additional","affiliation":[{"name":"Department of Surgery Londrina State University Londrina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deusdedit Brand\u00e3o","family":"Neto","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of S\u00e3o Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Voegels","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of S\u00e3o Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio D. R.","family":"Pinna","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of S\u00e3o Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22587"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22680"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13209"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-021-06839-w"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.622987"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820954825"},{"key":"e_1_2_12_8_1","article-title":"Interventions for the treatment of persistent post\u2010COVID\u201019 olfactory dysfunction","volume":"7","author":"O'Byrne L","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjaa066"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4576-x"},{"volume-title":"Logistic Regression Models","year":"2017","author":"Hilbe JM","key":"e_1_2_12_11_1"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.401"},{"key":"e_1_2_12_13_1","first-page":"202","article-title":"Effect of zinc sulfate on sensorineural olfactory disorder","volume":"538","author":"Aiba T","year":"1998","journal-title":"Acta Otolaryngol Suppl"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/15360288.2012.676618"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2014.07.014"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1909"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.029470"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.100981"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06520-8"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2020.102884"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10060698"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.4.414"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21293"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63855-7.00025-3"}],"container-title":["World Journal of Otorhinolaryngology - Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjo2.183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T05:01:31Z","timestamp":1717736491000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/wjo2.183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,13]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/wjo2.183"],"URL":"https:\/\/doi.org\/10.1002\/wjo2.183","archive":["Portico"],"relation":{},"ISSN":["2095-8811","2589-1081"],"issn-type":[{"type":"print","value":"2095-8811"},{"type":"electronic","value":"2589-1081"}],"subject":[],"published":{"date-parts":[[2024,5,13]]},"assertion":[{"value":"2023-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}