{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:34:42Z","timestamp":1787765682877,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["World j. otorhinolaryngol.-head neck surg."],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Unilateral vocal fold paralysis (ULVP) is characterized by the complete immobility of a single vocal fold which can cause significant health challenges, including voice impairment, difficulty swallowing, and a high risk of aspiration due to glottic incompetency. The aim of this study is to systematically review the effectiveness of laryngeal reinnervation (LR) and medialization thyroplasty (MT) in the treatment of ULVP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Medline, PubMed, Cochrane Library, OVID, Scopus, Springer Nature Journals, ScienceDirect, and Directory of Open Access Journals databases were searched. Restriction to non\u2010English studies were applied. Studies were excluded if subjects had previous treatment for ULVP, if they had co\u2010existing neuromuscular disease affecting the larynx, and if they had significant non\u2010laryngeal speech abnormalities<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifteen articles were reviewed, all conducted between 2003 and 2023. Among the 864 participants included, 48 underwent LR, 348 underwent MT, and the remaining 432 were in the comparison group, which involved injection laryngoplasty (IL), voice therapy (VT), placebo, and medialization with arytenoid adduction. Meta\u2010analyses compared LR to MT and MT to alternative treatments, revealing a preference for MT. The comparison between LR and MT in the network meta\u2010analysis yielded a mean difference of 0.33 (95% CI: \u221211.79, 12.6) favoring the MT group, ranking using SUCRA values highlighted that MT is the best treatment modality followed by LR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The results of the network meta\u2010analysis and the subgroup meta\u2010analysis showed that MT is better than alternative treatments that were included in this study. Moreover, management modalities should be individualized to each patient as many factors are important and may affect the final outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While the network meta\u2010analysis indicates that MT may be more effective than alternative treatments for managing ULVP, the results should be interpreted with caution due to potential confounding factors. One notable limitation is the small sample size in the LR group. Despite these limitations, the findings contribute to the existing literature and can help guide future research on optimal interventions for the treatment of ULVP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjo2.214","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T02:42:52Z","timestamp":1726108972000},"page":"449-461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effectiveness of laryngeal reinnervation compared to medialization thyroplasty in the treatment of unilateral vocal fold paralysis: A systematic review and network meta\u2010analysis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8196-9073","authenticated-orcid":false,"given":"Muhnnad A.","family":"AlGhamdi","sequence":"first","affiliation":[{"name":"College of Medicine King Saud bin Abdulaziz University for Health Sciences Jeddah Saudi Arabia"},{"name":"King Abdullah International Medical Research Center (KAIMRC) Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lama Nasser","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud bin Abdulaziz University for Health Sciences Jeddah Saudi Arabia"},{"name":"King Abdullah International Medical Research Center (KAIMRC) Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Khalid","family":"AlQazenli","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud bin Abdulaziz University for Health Sciences Jeddah Saudi Arabia"},{"name":"King Abdullah International Medical Research Center (KAIMRC) Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhay Saleh","family":"Alrashid","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud bin Abdulaziz University for Health Sciences Jeddah Saudi Arabia"},{"name":"King Abdullah International Medical Research Center (KAIMRC) Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab","family":"Bakhsh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine King Abdulaziz University Jeddah Saudi Arabia"},{"name":"Otolaryngology\u2010 Head &amp; Neck Surgery Department King Abdulaziz University Hospital Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2021.105906"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21754"},{"key":"e_1_2_11_4_1","article-title":"Unilateral vocal fold paralysis and voice therapy: predictors of long\u2010term quality of life","volume":"15","author":"Sousa F","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.886924"},{"key":"e_1_2_11_6_1","article-title":"Long\u2010term outcome of autologous lipoinjection medialization laryngoplasty versus type I thyroplasty","author":"Balouch B","year":"2023","journal-title":"J Voice"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816645765"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26773"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(03)00235-7"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2006.12.001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2020.08.026"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27140"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318137385e"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2019.09.017"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941212100308"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2017.02.015"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20982"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27684"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24623"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25739"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770272-9"}],"container-title":["World Journal of Otorhinolaryngology - Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjo2.214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T09:19:21Z","timestamp":1763457561000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/wjo2.214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,11]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/wjo2.214"],"URL":"https:\/\/doi.org\/10.1002\/wjo2.214","archive":["Portico"],"relation":{},"ISSN":["2095-8811","2589-1081"],"issn-type":[{"value":"2095-8811","type":"print"},{"value":"2589-1081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,11]]},"assertion":[{"value":"2024-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}