{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:56:38Z","timestamp":1792842998224,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["World j. otorhinolaryngol.-head neck surg."],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate complication rates of early adjuvant therapy initiation in pediatric patients with endoscopic endonasal resection for skull base tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective case series of pediatric patients (0\u201318 years old) with skull base tumors who underwent endoscopic endonasal resection between 2013 and 2023. The median follow\u2010up was 4.21 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Single, urban academic pediatric center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Patients who received radiation within 3 months and\/or chemotherapy within 2 weeks of endoscopic endonasal resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Primary outcomes were perioperative and adjuvant therapy\u2010related complications including reconstruction failure. Secondary outcomes were recurrence and overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study included 16 patients (radiation [\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910]; chemoradiation [\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092]; chemotherapy [\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094]) with a variety of tumor types and high dural reconstruction rate (93.8%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915). The average time to radiation was 39 days. The average time to chemotherapy was 9.5 days. The most common reconstructive method included nasoseptal flap and nasoseptal flap plus fat\/tensor fascia lata. No patients in either group experienced cerebrospinal fluid (CSF) leaks postoperatively or during adjuvant therapy. Only one patient experienced a recurrence post\u2010resection, and overall survival at the median follow\u2010up time was 91%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A majority of our patient cohort experienced intraoperative CSF leaks resulting in a high rate of complex endonasal reconstructions. Adjuvant treatment postoperatively did not incur significant complications, despite initiation of radiation as early as postoperative day 1 or chemotherapy as early as postoperative day 0, demonstrating preliminary support of the safety of early adjuvant therapy initiation following endoscopic endonasal procedures in the pediatric skull base tumor population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjo2.70004","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T12:32:09Z","timestamp":1741696329000},"page":"189-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early Initiation of Adjuvant Therapy Following Pediatric Endoscopic Endonasal Surgery for Tumors"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2256-9586","authenticated-orcid":false,"given":"Heta","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D.","family":"Workman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Massachusetts Eye and Ear Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Lerner","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Miami Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip J.","family":"Storm","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3634-2067","authenticated-orcid":false,"given":"Jennifer E.","family":"Douglas","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nithin D.","family":"Adappa","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James N.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Kohanski","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1395267"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-020-03465-0"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.9.JNS16559"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2005.19.1.4"},{"issue":"1","key":"e_1_2_11_6_1","first-page":"1","article-title":"Expanded Endonasal Approach: The Rostrocaudal Axis. Part II. Posterior Clinoids to the Foramen Magnum","volume":"19","author":"Kassam A.","year":"2005","journal-title":"Neurosurgical Focus"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-022-04103-7"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.7.FOCUS14350"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2005.19.1.7"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.724972"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3171\/2020.11.JNS202494"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2011.02.026"},{"key":"e_1_2_11_12_2","doi-asserted-by":"crossref","unstructured":"discussion:259\u2013262 https:\/\/doi.org\/10.1016\/j.wneu.2011.02.026.","DOI":"10.1016\/j.wneu.2011.02.026"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-020-01318-y"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3378"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.9035"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2021.100691"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-011-0589-2"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1023\/b:neon.0000040820.78643.0a"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noy001"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.369"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000234933.37779.e4"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000297074.13423.f5"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20216"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25395"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815571284"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812471808"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2015.09.013"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1617435"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23009"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342293"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3223"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1373659"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2114-4563"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noaa139"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.2547"}],"container-title":["World Journal of Otorhinolaryngology - Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjo2.70004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/wjo2.70004","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjo2.70004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T14:59:28Z","timestamp":1775228368000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/wjo2.70004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,10]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/wjo2.70004"],"URL":"https:\/\/doi.org\/10.1002\/wjo2.70004","archive":["Portico"],"relation":{},"ISSN":["2095-8811","2589-1081"],"issn-type":[{"value":"2095-8811","type":"print"},{"value":"2589-1081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,10]]},"assertion":[{"value":"2024-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}