{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T09:16:15Z","timestamp":1788167775041,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["World j. otorhinolaryngol.-head neck surg."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Insulin\u2010like growth factor 1 receptor (IGF\u20101R) is crucial for immunological control and the development of different types of cancer. It is still uncertain how the expression of IGF\u20101R impacts hypopharyngeal squamous cell carcinoma (HPSCC) and whether it has any predictive value for prognosis. Therefore, this study aimed to investigate the prognostic value of IGF\u20101R in HPSCC and its connection to tumor immunity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Correlation between IGF\u20101R, p16, and tumor\u2010infiltrating immune cells from the TCGA HNSCC data set was analyzed. The expressions of IGF\u20101R and programmed death ligand (PD\u2010L1) and immune cell density were analyzed using immunohistochemistry (IHC) and multiplex immunohistochemistry (mIHC) in p16+\/p16\u2212 HPSCC. Overall, 114 surgical specimens from 51 p16+ patients and 63 p16\u2212 patients with a bioptic diagnosis of HPSCC who underwent surgical resection at the Second Affiliated Hospital of Harbin Medical University were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IGF\u20101R and PD\u2010L1 were expressed in tumor cells and invasion\u2010front immune cells. Expression of IGF\u20101R and PD\u2010L1 was related to tumor grade and lymph node status. In patients with p16\u2212 HPSCC, IGF\u20101R and PD\u2010L1 expression were significantly higher than those with p16+ HPSCC, as were CD68+ or CD163+ cell densities. PD\u2010L1 expression and CD68+ macrophage density were positively correlated with IGF\u20101R expression in p16+ HSPCC. In the p16+ HPSCC group, the co\u2010expression rate of IGF\u20101R\/PD\u2010L1 was significantly increased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IGF\u20101R expression could potentially serve as a better predictor of PD\u20101\/PD\u2010L1 inhibitor response rate in patients with HPSCC compared to p16 status. Combination therapy using IGF\u20101R inhibitors and PD\u20101\/PD\u2010L1 blockade may prove to be an effective treatment approach for patients with p16+ HPSCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjo2.70025","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T04:26:30Z","timestamp":1747628790000},"page":"112-123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Insulin\u2010Like Growth Factor 1 Receptor Expression for Predicting PD\u20111\/PD\u2011L1 Inhibitor Response in Hypopharyngeal Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"12","author":[{"given":"Wen\u2010Jing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery The First Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Lin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery The First Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Cheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Head and neck Surgery Guangxi Medical University Cancer Hospital &amp; Guangxi Cancer Institute Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun\u2010Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University Chinese Ministry of Education Harbin 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The Second Affiliated Hospital of Harbin Medical University Chinese Ministry of Education Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng\u2010Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery The First Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University Chinese Ministry of Education Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8934-1607","authenticated-orcid":false,"given":"Lin\u2010Li","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery The First Affiliated Hospital of Harbin Medical 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