{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:48:45Z","timestamp":1791787725299,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["World j. otorhinolaryngol.-head neck surg."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sinonasal malignancies with orbital involvement may be managed with orbit\u2010sacrificing or orbit\u2010preserving surgical approaches, with a recent shift towards orbital preservation to reduce postoperative morbidity while maintaining oncological success. The current clinical data on the most optimal approach for managing such locally advanced tumours remains inconclusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Embase, and SCOPUS were searched from inception to 12 June 2024 for longitudinal studies investigating oncological and functional outcomes in sinonasal malignancies with orbital involvement managed with orbit\u2010sacrificing vs. orbit\u2010preserving surgery. Two independent authors selected relevant articles, extracted data, assessed bias using the Newcastle\u2010Ottawa Scale and evaluated quality of evidence following the Grading of Recommendations, Assessment, Development and Evaluations framework. Random\u2010effects meta\u2010analysis was performed to synthesise pooled oncological outcomes, while descriptive reviews were performed for functional outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis of 12 studies and 758 participants found that the 5\u2010year overall survival rate of patients managed with orbit\u2010preserving surgery (55%, 95% CI: 0.32\u20130.76) was comparable to that in patients managed with orbit\u2010sacrificing surgery (53%, 95% CI: 0.34\u20130.70). The 5\u2010year recurrence\u2010free survival rate was significantly higher in patients managed with orbit\u2010preserving surgical intervention (64%, 95% CI: 0.44\u20130.80), compared to those with orbit\u2010sacrificing surgery (48%, 95% CI: 0.13\u20130.84). Descriptive review showed good functional outcomes in patients managed with orbit\u2010preserving surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Orbit\u2010preserving surgery in selected cases of sinonasal malignancies with orbital involvement is oncologically safe and can allow for the maintenance of a functionally useful eye. Greater number of large\u2010scale, robust studies are required to further evaluate the outcomes in tumours with different characteristics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjo2.70049","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T06:43:58Z","timestamp":1754981038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Outcomes in Orbit\u2010Sparing Versus Orbit\u2010Sacrificing Surgery for Sinonasal Malignancies With Orbital Involvement: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4529-2978","authenticated-orcid":false,"given":"Claire Jing\u2010Wen","family":"Tan","sequence":"first","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian Sheng Yep","family":"Yeo","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Warrier","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun He","family":"Chan","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu Hui","family":"Png","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head &amp; Neck Surgery Singapore General Hospital Singapore Singapore"},{"name":"Surgery Academic Clinical Program, SingHealth Singapore Singapore"},{"name":"Faculty of Medicine and Health Sciences, Macquarie University Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head &amp; Neck Surgery Singapore General Hospital Singapore Singapore"},{"name":"Surgery Academic Clinical Program, SingHealth Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley LiQin","family":"Kiong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head &amp; Neck Surgery Singapore General Hospital Singapore Singapore"},{"name":"Surgery Academic Clinical Program, SingHealth Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward C.","family":"Kuan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery and Neurological Surgery University of California, Irvine Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze Choong","family":"Charn","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head &amp; 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