{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:01:01Z","timestamp":1767175261178,"version":"3.48.0"},"reference-count":84,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["World j. otorhinolaryngol.-head neck surg."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Upper airway cough syndrome (UACS) has been identified as a significant contributor to chronic cough in various national guidelines. However, the complexity of its pathogenesis, the lack of clarity surrounding its diagnostic criteria, and its overlap with other etiologies of chronic cough present considerable challenges in both diagnosis and treatment. The utilization of nasal and laryngeal endoscopy is crucial in the diagnostic process, and the implementation of a multidisciplinary collaborative approach can markedly enhance diagnostic accuracy and treatment outcomes. This article provides a comprehensive review of the clinical characteristics, diagnostic and therapeutic approaches, and pathophysiological mechanisms associated with UACS, aiming to equip clinicians with a deeper understanding for improved management of this condition.<\/jats:p>","DOI":"10.1002\/wjo2.70073","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T09:56:28Z","timestamp":1767174988000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Research Progress on Upper Airway Cough Syndrome"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0441-2532","authenticated-orcid":false,"given":"Wan\u2010Ting","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine Zhejiang University Yiwu China"},{"name":"The Department of Otolaryngology, The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Chen","sequence":"additional","affiliation":[{"name":"The Department of Otolaryngology, The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112147-20211101-00759"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2010.tb03504.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0808-7409"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.1_suppl.63S"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1673-0860.2019.02.001"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1673-0860.2010.12.003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn115330-20211228-00828"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2024.02.017"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kjms.2015.01.005"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01136-2019"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-009-9185-z"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(13)70043-2"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2011.576249"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.01.038"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-018-1376-6"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998901030S505"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-015-0907-7"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-014-0762-y"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2010.tb03682.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2024.08.007"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-023-00666-y"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112147-20210320-00186"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2019.03.007"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61255-1"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00725-2021"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-1533"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11202733"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2017.06.009"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-201443"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01144.2012"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.044"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00370-w"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.149.10.3309"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100028"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13601-015-0069-4"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2017.01.010"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207425"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4597-10.2011"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00600.2009"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-1481"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-9974-8-11"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2013.3.2.127"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2008.11.014"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2010.05.015"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.889118"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1991.tb00559.x"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.038"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3456"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.148379"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/39807"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201508-1602OC"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200703-457OC"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm-conference.2014.189.1_MeetingAbstracts.A3969"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm-conference.2016.193.1_MeetingAbstracts.A6002"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.04.038"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2016.03.007"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4125"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30951"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200062200"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-15-06408.2002"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00559.2002"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.121111"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00016.2006"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature719"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(02)00652-9"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.01.016"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2004.09.004"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2726261"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1671-6205.2009.03.012"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1005-2194.2007.07.019"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-024-01089-4"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2019.1654377"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.05.001"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01452-2016"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-1077-z"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200903-0388OC"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00405-2015"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2011.07.010"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3180ca7846"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2011.1.3.152"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0091-6749(05)80126-5"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25335"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.04.009"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22741"}],"container-title":["World Journal of Otorhinolaryngology - Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjo2.70073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T09:56:33Z","timestamp":1767174993000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/wjo2.70073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,31]]},"references-count":84,"alternative-id":["10.1002\/wjo2.70073"],"URL":"https:\/\/doi.org\/10.1002\/wjo2.70073","archive":["Portico"],"relation":{},"ISSN":["2095-8811","2589-1081"],"issn-type":[{"value":"2095-8811","type":"print"},{"value":"2589-1081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,31]]},"assertion":[{"value":"2025-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"wjo2.70073"}}