{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T07:15:00Z","timestamp":1764918900219,"version":"3.46.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["World j. otorhinolaryngol.-head neck surg."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study retrospectively analyzes two mandibular resection techniques for T3\u2010stage lower gingival carcinoma, aiming to compare their impact on patient prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study. Data from 78 cases of T3\u2010stage lower gingival carcinoma involving the mandible were reviewed in our Department of Head and Neck Surgery. These cases included patients who underwent either marginal mandibulectomy or segmental mandibulectomy. A cohort analysis was performed to evaluate the clinical outcomes and identify factors influencing prognosis in T3\u2010stage lower gingival carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010eight patients underwent marginal mandibulectomy, while 40 underwent segmental mandibulectomy. The 3\u2010year overall survival (OS) rate in the marginal mandibulectomy group was 70.8%, with a 5\u2010year OS rate of 52.1%. In the segmental mandibulectomy group, the 3\u2010year OS was 68.1%, and the 5\u2010year OS rate was 52.7%, with no statistically significant difference between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). The 3\u2010year disease\u2010free survival (DFS) rate was 67.4% in the marginal mandibulectomy group and 50.7% at 5 years, compared to 62.2% and 57.4%, respectively, in the segmental resection group, again showing no statistically significant difference in DFS between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). However, patients in the marginal resection group demonstrated superior postoperative mandibular functional preservation. Multivariate Cox regression analysis identified advanced age, lymph node metastasis, poor pathological differentiation, and lack of adjuvant radiotherapy as independent risk factors for poor prognosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The marginal mandibulectomy has been proven to be an oncologically safe method with satisfactory mandibular functional outcomes in selected cases of T3\u2010stage lower gingival carcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjo2.70074","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T06:40:47Z","timestamp":1764916847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Retrospective Study of Two Mandibulectomy Approaches for T3\u2010Stage Lower Gingival Carcinoma"],"prefix":"10.1002","author":[{"given":"Hang","family":"Ling","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Xiao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wai\u2010Sheng","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9800-263X","authenticated-orcid":false,"given":"Hai\u2010Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9785-858X","authenticated-orcid":false,"given":"Ping\u2010Qing","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-016-0078-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.06.018"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.5.604"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21530"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0266-4356(02)00116-x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2004.12.002"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.5.600"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24962"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-016-0211-1"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otorri.2017.03.004"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e328350a5cc"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.22017"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000394"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28388"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12397"},{"issue":"1","key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/00006534-198907000-00014","article-title":"Fibula Free Flap: A New Method of Mandible Reconstruction","volume":"84","author":"Hidalgo D. 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