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However, the nature of these associations remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study was conducted between January 2020 and December 2024. A total of 308 patients with SSNHL who received short\u2010term combined therapy and 169 healthy controls were included from our hospital. Initially, baseline clinical indicators were compared between the patient group and the control group. Subsequently, patients were further stratified into four subgroups according to their hearing recovery outcomes for more detailed inter\u2010group comparisons, and the impact of these indicators on SSNHL incidence and prognosis was assessed. To further investigate potential causality, Mendelian randomization (MR) analysis was performed to examine the relationship between genetically predicted blood components and SSNHL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our retrospective analysis revealed significant differences between the patient and control groups in the following parameters at admission: plasma fibrinogen at admission (PRE\u2010FIB), activated partial thromboplastin time (APTT), thrombin time (TT), prothrombin time (PT), total cholesterol (CHOL), high\u2010density lipoprotein cholesterol (HDL\u2010C), low\u2010density lipoprotein cholesterol (LDL\u2010C), and triglycerides (TG). Among the four groups stratified by hearing recovery, differences were observed in admission hearing level (dB), the change in plasma fibrinogen after the first batroxobin injection relative to baseline (DIFF\u2010FIB), and CHOL. MR analysis using the random\u2010effects inverse\u2010variance weighted (IVW) method indicated a significant causal relationship between genetically predicted lipid levels and SSNHL. Additionally, genetically predicted S\u2010adenosylhomocysteine and fibrinogen were identified as potential risk factors for SSNHL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PRE\u2010FIB, APTT, TT, PT, CHOL, HDL\u2010C, LDL\u2010C, and TG may be associated with the onset of SSNHL. Admission hearing level (dB), DIFF\u2010FIB, and CHOL could play a role in predicting hearing recovery after SSNHL. MR analysis provides causal evidence supporting lipids, fibrinogen, and S\u2010adenosylhomocysteine as potential risk factors for SSNHL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjo2.70107","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T04:31:15Z","timestamp":1779078675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Relationship Between Blood Lipids, Coagulation Indexes, Blood Homocysteine and Sudden Deafness: A Retrospective Study and Mendelian Randomization Analysis"],"prefix":"10.1002","author":[{"given":"Feng\u2010Xin","family":"Yang","sequence":"first","affiliation":[{"name":"Hearing and Speech Rehabilitation institute, School of Special Education and Rehabilitation Binzhou Medical University Yantai China"},{"name":"Department of Otolaryngology, Head and Neck Surgery Yantai Yuhuangding Hospital Qingdao University Yantai Shandong China"},{"name":"Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases Yantai Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Wan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Yantai Yuhuangding Hospital Qingdao University Yantai Shandong China"},{"name":"Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases Yantai Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Yantai Yuhuangding Hospital Qingdao University Yantai Shandong China"},{"name":"Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases Yantai Shandong China"},{"name":"The Second School of Clinical Medicine of Binzhou Medical University Yantai Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu\u2010Hui\u2010Fen","family":"He","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Yantai Yuhuangding Hospital Qingdao University Yantai Shandong China"},{"name":"Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases Yantai Shandong China"},{"name":"The Second School of Clinical Medicine of Binzhou Medical University Yantai Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing\u2010Jing","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery 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