{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T10:22:19Z","timestamp":1787826139977,"version":"build-2784847793"},"reference-count":68,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["World j. otorhinolaryngol.-head neck surg."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Budesonide is a corticosteroid with unique pharmacokinetic and pharmacodynamic properties that has been a frontline treatment for patients with allergic rhinitis (AR) and chronic rhinosinusitis (CRS) since the 1990s. As research on budesonide continues to produce new insights, our aim was to synthesize recent investigations and provide up\u2010to\u2010date information on safety, clinical, and mechanism of action (MOA) outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>Searches were restricted to PubMed from 2014\/01\/01 to 2025\/02\/26. Clinical investigations in the primary therapeutic area of rhinitis, sinusitis, or rhinosinusitis with adult patients receiving budesonide were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>Results were screened, and findings from eligible articles were assessed for safety, efficacy, and\/or MOA outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 31 articles were included. CRS was the primary indication in 19 studies and rhinitis in 12 (predominantly AR). Six studies investigated hypothalamic\u2013pituitary\u2013adrenal (HPA) axis suppression, and 2 studies assessed intraocular pressure; budesonide did not adversely affect either outcome, even with long\u2010term, high\u2010dose, high\u2010volume nasal irrigations. Twelve studies of budesonide monotherapy generally showed improved efficacy outcomes. Eight studies of budesonide combination therapies, predominantly in patients with moderate\u2010to\u2010severe AR, generally showed improved efficacy versus budesonide monotherapy. MOA data were reported across seven studies, with anti\u2010inflammatory alterations observed across the nasal mucosa, nasal secretions, nasal polyps, and peripheral blood after budesonide treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Safety outcomes were favorable across various budesonide delivery systems, including high\u2010dose, high\u2010volume nasal irrigations, with no evidence of HPA axis suppression after long\u2010term budesonide use. Budesonide demonstrated consistent efficacy that was underpinned by MOA data on its potent anti\u2010inflammatory effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjo2.70114","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:58:01Z","timestamp":1787824681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety, Efficacy, and Mechanism of Action of Budesonide in Rhinitis and Rhinosinusitis: A Systematic Review"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0171-1336","authenticated-orcid":false,"given":"David W.","family":"Kennedy","sequence":"first","affiliation":[{"name":"Sidney Kimmel Medical School Thomas Jefferson University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The First Affiliated Hospital with Nanjing Medical University Nanjing China"},{"name":"Department of Allergology &amp; Clinical Allergy Center The First Affiliated Hospital with Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De\u2010Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.68607"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.03.002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S482258"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2017.1294063"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.09.002"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-024-08901-9"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.5826\/mrm.2025.1015"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1184552"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.07.007"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23090"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-020-00480-z"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/jaa.S321332"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0091-6749(99)70059-x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61893-5"},{"issue":"2","key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.4172\/2167-1052.1000148","article-title":"High Volume Sinonasal Budesonide Irrigations for Chronic Rhinosinusitis: An Update on the Safety and Effectiveness","volume":"3","author":"Rudmik L.","year":"2014","journal-title":"Advances in Pharmacoepidemiology & Drug Safety"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.21315\/mjms2022.29.1.4"},{"key":"e_1_2_11_18_1","unstructured":"U.S. Food and Drug Administration Rhinocort Aqua. 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