{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:24:57Z","timestamp":1787300697792,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["World j. otorhinolaryngol.-head neck surg."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Identifying extramedullary plasmacytoma originating from the base\u2010of\u2010tongue, in order to evaluate its prevalence, characteristics, management, and treatment within the broader spectrum of head and neck extramedullary plasmacytoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>A systematic review was conducted in PubMed, Web of Science, and Cochrane Library for publications up to August 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eligible studies were in English, verified by two reviewers independently. Articles were excluded if they lacked a diagnosis of extramedullary plasmacytoma, and localization to the base\u2010of\u2010tongue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010five studies (case reports and case series) comprising of 30 individual cases were identified. The mean age was 63.6 years, with a male\u2010to\u2010female ratio of 5.25:1. Common symptoms included odynophagia, dysphagia, and sore throat. Tumors were confined to the base of tongue in 44% of cases, with others involving cervical lymph nodes or adjacent sites. All specimens showed plasma cell histology; bone marrow, Bence\u2010Jones, and skeletal surveys were negative. Imaging (CT, PET\u2010CT, MRI) revealed additional sites in a minority. Radiotherapy was the main treatment (23 patients, mean dose 45\u2009Gy), often combined with surgery or chemotherapy. Mean follow\u2011up was 47.7 months, with generally favorable survival, though four cases had recurrence or partial control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this review, 30 cases were identified, all meeting accepted diagnostic criteria for extramedullary plasmacytoma with exclusion of other plasma cell disorders. Radiotherapy was the most frequent treatment modality with survival among described cases as generally favorable. Extramedullary plasmacytoma should be included in the differential diagnosis of lesions arising in the base of tongue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjo2.70156","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T07:56:03Z","timestamp":1787298963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extramedullary Plasmacytoma of Base of Tongue: A Systematic Review"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7362-3343","authenticated-orcid":false,"given":"Ori Cohen","family":"Michael","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Meir Medical Center Kfar Saba Israel"},{"name":"Joyce and Irvin Goldman Medical School, Faculty of Health Sciences Ben Gurion University of the Negev Beer\u2010Sheba Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0901-2302","authenticated-orcid":false,"given":"Ameen","family":"Biadsee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Meir Medical Center Kfar Saba Israel"},{"name":"Gray School of Medical Sciences, Faculty of Medical and Health Sciences Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3715-1120","authenticated-orcid":false,"given":"Firas","family":"Kassem","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Meir Medical Center Kfar Saba Israel"},{"name":"Gray School of Medical Sciences, Faculty of Medical and Health Sciences Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0007-5422","authenticated-orcid":false,"given":"Matan","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Meir Medical Center Kfar Saba Israel"},{"name":"Gray School of Medical Sciences, Faculty of Medical and Health Sciences Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osnat","family":"Jarchowsky\u2010Dolberg","sequence":"additional","affiliation":[{"name":"Gray School of Medical Sciences, Faculty of Medical and Health Sciences Tel Aviv University Tel Aviv Israel"},{"name":"Hematology Institute Meir Medical Center Kfar Saba Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6686-2565","authenticated-orcid":false,"given":"Benny","family":"Nageris","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Meir Medical Center Kfar Saba Israel"},{"name":"Gray School of Medical Sciences, Faculty of Medical and Health Sciences Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1839-7344","authenticated-orcid":false,"given":"Tomer","family":"Boldes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Meir Medical Center Kfar Saba Israel"},{"name":"Gray School of Medical Sciences, Faculty of Medical and Health Sciences Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0360-3016(02)02780-3"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20821"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0044-1787535"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21254"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07421.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/238698"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4817-z"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(194903)2:2<261::aid-cncr2820020206>3.0.co;2-k"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(86)70038-8"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197906)43:6<2340::aid-cncr2820430625>3.0.co;2-m"},{"key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2214\/ajr.108.1.149","article-title":"Pseudolymphomas","volume":"108","author":"Robbins R.","year":"1970","journal-title":"American Journal of Roentgenology Radium Therapy and Nuclear Medicine"},{"key":"e_1_2_12_13_1","first-page":"243","volume-title":"Operative Otolaryngology","author":"Petruzzelli G.","year":"2018"},{"key":"e_1_2_12_14_1","unstructured":"U.S. National Library of Medicine. 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