{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:16:51Z","timestamp":1788340611289,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["World j. otorhinolaryngol.-head neck surg."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic respiratory diseases impose a large global burden of morbidity, mortality, and cost. The concept of a global airway has become increasingly supported by epidemiologic, mechanistic, and clinical evidence. However, clinical care often remains fragmented between ear, nose, and throat (ENT), allergy, and pulmonology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multidisciplinary expert panel composed of allergists, pulmonologists, and otolaryngologists from multiple tertiary care centres was convened. Experts were selected using predefined criteria encompassing clinical experience, academic output, geographic and institutional diversity, and gender balance. The panel performed a structured synthesis of current international guidelines and high\u2010impact literature, using a modified Delphi consensus process over 3 rounds, with a predefined agreement threshold of \u2265\u200980% to define the scope of diseases, diagnostic approach, and interdisciplinary care model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Global Airways Unit (GAU) framework prioritizes multidisciplinary teamwork, early detection of comorbidities, phenotype\u2011directed investigations, streamlined imaging, and assignment of a lead specialty with scheduled follow\u2011up. Expected benefits include earlier diagnosis, improved disease control and quality of life (QoL), reduced duplication of testing, and potential cost\u2011savings for patients and health systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The GAU operationalises the unified airway hypothesis into a reproducible clinical model. We propose the formation of a GAU to coordinate the management of patients with inflammatory airway diseases. Prospective real\u2011world evaluation of GAU implementation is the next critical step to validate clinical and economic outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjo2.70166","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:34:53Z","timestamp":1788338093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Global Airways Unit: A Multidisciplinary Strategy for Early Diagnosis and Comorbidity Detection"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8896-495X","authenticated-orcid":false,"given":"Diego M.","family":"Conti","sequence":"first","affiliation":[{"name":"Escuela de Doctorado UAM, Centro de Estudios de Posgrado Universidad Aut\u00f3noma de Madrid. Calle Francisco Tom\u00e1s y Valiente, n\u00b0 2. Ciudad Universitaria de Cantoblanco Madrid Spain"},{"name":"Allergy and Clinical Immunology Research Unit, Department of Microbiology and Immunology KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6141-5360","authenticated-orcid":false,"given":"Eduardo J.","family":"Correa","sequence":"additional","affiliation":[{"name":"Departamento de Otorrinolaringolog\u00eda Quironsalud Marbella y Hospital Campo de Gibraltar Marbella Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4332-0920","authenticated-orcid":false,"given":"Alfonso","family":"Del Cuvillo","sequence":"additional","affiliation":[{"name":"Rhinology and Asthma Unit, ENT Department Hospital Universitario de Jerez Jerez de la Frontera Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2848-2411","authenticated-orcid":false,"given":"Jos\u00e9 D.","family":"Abdullatif","sequence":"additional","affiliation":[{"name":"Departamento de Otorrinolaringolog\u00eda Hospital Brit\u00e1nico de Buenos Aires Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0175-2824","authenticated-orcid":false,"given":"Francisco J.","family":"Alvarez\u2010Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Unidad de Asma. Hospital Universitario Virgen del Roc\u00edo Sevilla Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1748-2195","authenticated-orcid":false,"given":"Remedios C\u00e1rdenas","family":"Contreras","sequence":"additional","affiliation":[{"name":"Servicio de Alergolog\u00eda. Hospital Universitario Virgen del Roc\u00edo Sevilla Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6453-0225","authenticated-orcid":false,"given":"Stefan","family":"Cimbollek","sequence":"additional","affiliation":[{"name":"Servicio de Alergolog\u00eda. Hospital Universitario Virgen del Roc\u00edo Sevilla Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo Corrales","family":"Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Servicio de Otorrinolaringolog\u00eda. 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