{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:41:21Z","timestamp":1792755681067,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["World j. otorhinolaryngol.-head neck surg."],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sinonasal inverted papilloma (IP) and malignancies share overlapping clinical and endoscopic features, and conventional histopathology frequently requires time\u2010consuming adjunct immunohistochemistry. Hyperspectral imaging (HSI) can capture subtle spectral changes associated with malignant transformation that are not apparent on routine hematoxylin\u2010eosin (H&amp;E) staining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective single\u2010center study, 176 H&amp;E\u2010stained surgical specimens from 176 patients (89 with IP and 87 with sinonasal malignancies) were allocated at the patient\/specimen level to training, validation, and test sets in a 6:2:2 ratio before any hyperspectral data processing. Hyperspectral calibration, selection of regions of interest (ROIs), spectral preprocessing, feature extraction, and quality control yielded 9,296 eligible ROI\u2010level hyperspectral samples: 5,578 in the training set, 1,859 in the validation set, and 1,859 in the test set. Joint spectral\u2010texture features were evaluated using several reference deep\u2010learning models and a Transformer\u2010Attention\u2010based Network (TAT\u2010Net). The primary outcome was the area under the receiver operating characteristic curve (AUC) in the test set.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HSI revealed distinct spectral signatures between IP and sinonasal malignancies. All deep learning models demonstrated good discriminative performance (AUCs \u2265\u20090.85), with TAT\u2010Net achieving the best overall performance. On the independent test set, TAT\u2010Net achieved an AUC of 0.9656 (95% CI: 0.9571\u20130.9741) for distinguishing between IP and sinonasal malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AI\u2010powered TAT\u2010Net analysis of HSI enables rapid and accurate differentiation between IP and sinonasal malignancies on routine H&amp;E sections. This approach has the potential to shorten diagnostic workflows, support early decision\u2010making, and help standardize the evaluation of sinonasal tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjo2.70170","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T10:47:34Z","timestamp":1790160454000},"page":"611-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["AI\u2010Powered TAT\u2010Net Hyperspectral Imaging for Rapid and Accurate Differentiation of Sinonasal Inverted Papilloma and Malignancy"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9965-7518","authenticated-orcid":false,"given":"Hao\u2010Miao","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, National Health Commission Key Laboratory of Otorhinolaryngology Shandong Provincial Key Medical and Health Discipline of Qilu Hospital of Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Chang","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Institute, School of Control Science and Engineering Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Ze","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Institute, School of Control Science and Engineering Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7367-4178","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Institute, School of Control Science and Engineering Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8089-4005","authenticated-orcid":false,"given":"Xin","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, National Health Commission Key Laboratory of Otorhinolaryngology Shandong Provincial Key Medical and Health Discipline of Qilu Hospital of Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.97"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2012.08.004"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28108"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-025-11655-5"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.47162\/RJME.61.4.30"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1117\/12.912026"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202500227"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202300174"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.17.7.076005"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol30010042"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-025-01981-9"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106527"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.10.006370"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/s20071911"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13184593"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin25.073"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.577655"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2017.10.010"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11133575"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12040837"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i1.108"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-21-806"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12071884"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23083"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.12.002"}],"container-title":["World Journal of Otorhinolaryngology - 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