{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:51:43Z","timestamp":1791453103583,"version":"4.3.3"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["World j. otorhinolaryngol.-head neck surg."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Biologic therapies are effective for severe, uncontrolled CRSwNP, yet real\u2010world data on treatment persistence remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective single\u2010center study included 95 adults with CRSwNP who initiated dupilumab (88.4%), mepolizumab, or omalizumab between 2021 and 2025. The primary outcome was persistence with the index biologic therapy. Discontinuation was a permanent cessation, switching, or a\u2009\u2265\u200990\u2010day dosing gap. Switching ended index\u2010biologic persistence but not biologic therapy overall. Response was graded with European Position Paper on Rhinosinusitis and Nasal Polyps\/European Forum for Research and Education in Allergy and Airway Diseases (EPOS\/EUFOREA) criteria. Kaplan\u2010Meier and Cox analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010one patients (22.1%) discontinued their index biologic over a median follow\u2010up of 18 months. Eight switched agents, so 13 (13.7%) stopped biologic therapy altogether. Index\u2010biologic persistence was 82.3% (95% CI: 71.9%\u201389.2%) at 12 months and 71.7% (95% CI: 58.2%\u201381.5%) at 30 months. Among discontinuers, the median observed time to discontinuation was 9.4 months. Adverse events were the leading cause (57.1%), most commonly arthralgia and ocular symptoms. Early discontinuation was driven predominantly by adverse events, whereas adverse events and insufficient efficacy contributed equally later. In exploratory univariable Cox analyses, adverse events during therapy (HR\u2009=\u20094.32, 95% CI: 1.73\u201310.79) and a general history of allergy (HR\u2009=\u20093.07, 95% CI: 1.24\u20137.58) were most strongly associated with discontinuation, as were female sex, diabetes mellitus, and lower EPOS\/EUFOREA response scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this real\u2010world cohort, discontinuation of the index biologic was driven mainly by adverse events and insufficient response. Early follow\u2010up focused on tolerability and later review on disease control may be warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjo2.70183","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:13:25Z","timestamp":1791450805000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment Persistence and Factors Associated With Discontinuation in Real\u2010World Biologic Therapy for Chronic Rhinosinusitis With Nasal Polyps"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2433-0798","authenticated-orcid":false,"given":"Hen","family":"Chaushu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery and Maxillofacial Surgery Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Gray Faculty of Medical &amp; Health Science Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuval","family":"Presman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery and Maxillofacial Surgery Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Gray Faculty of Medical &amp; Health Science Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0499-7387","authenticated-orcid":false,"given":"Roni","family":"Vass","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery and Maxillofacial Surgery Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Gray Faculty of Medical &amp; Health Science Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0628-1942","authenticated-orcid":false,"given":"Narin Nard","family":"Carmel\u2010Neiderman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery and Maxillofacial Surgery Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Gray Faculty of Medical &amp; Health Science Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2745-2088","authenticated-orcid":false,"given":"Liyona","family":"Kampel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery and Maxillofacial Surgery Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Gray Faculty of Medical &amp; 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