{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:46:02Z","timestamp":1791791162349,"version":"4.3.4"},"reference-count":79,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["World j. otorhinolaryngol.-head neck surg."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To summarize current Western and Eastern approaches to the evaluation and management of chronic cough, with particular emphasis on etiology\u2010directed therapy, cough hypersensitivity, behavioral interventions, neuromodulators, procedural treatments, and traditional remedies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature search of PubMed, Web of Science, CNKI, and Ovid Medline was conducted on February 1, 2024. Adults with chronic cough lasting at least 8 weeks were eligible. Pediatric studies, studies involving immunocompromised patients, smokers or patients with lung cancer, animal studies, and non\u2010English or non\u2010Mandarin publications were excluded. Because of substantial heterogeneity in etiologies, interventions, study designs, and outcome measures, findings were synthesized narratively rather than quantitatively. Twenty\u2010three primary studies were included in the final narrative synthesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Chronic cough commonly reflects cough hypersensitivity involving vagal sensory pathways and receptors including TRPV1, TRPA1, and P2X3. Common clinical contributors included upper airway cough syndrome, gastro\u2010esophageal reflux disease, and cough\u2010variant asthma. Management was most appropriately organized as a stepwise approach involving identification and treatment of the underlying cause, behavioral cough suppression therapy, and selected pharmacological treatment. Gabapentin and P2X3 antagonists may benefit refractory cough, although adverse effects and limited long\u2010term data remain important limitations. Superior laryngeal nerve block and antireflux surgery may be considered in carefully selected patients. Acupuncture and selected traditional preparations may provide adjunctive benefit, but the evidence remains heterogeneous and should not replace standard evaluation or treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Chronic cough should be managed using a personalized, stepwise strategy that combines etiology\u2010directed treatment with interventions targeting cough hypersensitivity. Traditional therapies may have a complementary role, but further well\u2010designed comparative studies are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjo2.70185","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:58:46Z","timestamp":1791788326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Where Eastern Medicine Meets Western Medicine: A World Review of the Management of Chronic Cough"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7355-9591","authenticated-orcid":false,"given":"Thomas Zheng Jie","family":"Teng","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Sengkang General Hospital Singhealth Singapore"},{"name":"School of Public Health Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi Xuan","family":"Koh","sequence":"additional","affiliation":[{"name":"Ministry of Health Holdings Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3919-4343","authenticated-orcid":false,"given":"Justin Yi Shen","family":"Lim","sequence":"additional","affiliation":[{"name":"Ministry of Health Holdings Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavimalar","family":"Ravi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Sengkang General Hospital Singhealth Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Wayne Kyler","family":"Ong","sequence":"additional","affiliation":[{"name":"Ministry of Health Holdings Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7656-7044","authenticated-orcid":false,"given":"Christina Hui Lee","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Sengkang General Hospital Singhealth Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.064337"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-22-1435"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-0441"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2019.101811"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.07.014"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.1019"},{"key":"e_1_2_13_8_1","first-page":"644","article-title":"[OCEBM Levels of Evidence System]","volume":"68","author":"Durieux N.","year":"2013","journal-title":"Revue Medicale de Liege"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0127-2021"},{"key":"e_1_2_13_10_1","volume-title":"Cough","author":"Sharma S.","year":"2025"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2017.06.009"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.10003"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00748.2002"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-014-1082-1"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00370-w"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2023.102252"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205661"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.2_supplement.133s"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2022.09.011"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934400"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.1_suppl.63S"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-9974-8-11"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2013.3.2.127"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.05.048"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2011.01.011"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004823.pub4"},{"key":"e_1_2_13_27_1","first-page":"512","article-title":"Laryngopharyngeal Reflux and Functional Laryngeal Disorder: Perspective and Common Practice of the General Gastroenterologist","volume":"14","author":"Patel D. 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