{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T11:30:21Z","timestamp":1788607821490,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Low\u2010grade appendiceal mucinous neoplasms (LAMN) are very rare, accounting for approximately 0.2%\u20130.5% of gastrointestinal tumors. We conducted a multicenter retrospective study to explore the impact of different surgical procedures combined with HIPEC on the short\u2010term outcomes and long\u2010term survival of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the clinicopathological data of 91 LAMN perforation patients from 9 teaching hospitals over a 10\u2010year period, and divided them into HIPEC group and non\u2010HIPEC group based on whether or not underwent HIPEC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 91 patients with LAMN, 52 were in the HIPEC group and 39 in the non\u2010HIPEC group. The Kaplan\u2010Meier method predicted that 52 patients in the HIPEC group had 5\u2010 and 10\u2010year overall survival rates of 82.7% and 76.9%, respectively, compared with predicted survival rates of 51.3% and 46.2% for the 39 patients in the non\u2010HIPEC group, with a statistically significant difference between the two groups (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a010.622, <jats:bold><jats:italic>p<\/jats:italic><\/jats:bold>\u00a0=\u00a00.001; <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a010.995, <jats:bold><jats:italic>p<\/jats:italic><\/jats:bold>\u00a0=\u00a00.001). Compared to the 5\u2010year and 10\u2010year relapse\u2010free survival rates of 75.0% and 65.4% in the HIPEC group, respectively, the 5\u2010year and 10\u2010year relapse\u2010free survival rates of 48.7% and 46.2% in the non\u2010HIPEC group were significant different between the two outcomes (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a08.063, <jats:bold><jats:italic>p<\/jats:italic><\/jats:bold>\u00a0=\u00a00.005; <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a06.775, <jats:bold><jats:italic>p<\/jats:italic><\/jats:bold>\u00a0=\u00a00.009). The incidence of postoperative electrolyte disturbances and hypoalbuminemia was significantly higher in the HIPEC group than in the non\u2010HIPEC group (<jats:bold><jats:italic>p<\/jats:italic><\/jats:bold>\u00a0=\u00a00.023; <jats:bold><jats:italic>p<\/jats:italic><\/jats:bold>\u00a0=\u00a00.044).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study shows that surgery combined with HIPEC can significantly improve 5\u2010year and 10\u2010year overall survival rates and relapse\u2010free survival rates of LAMN perforation patients, without affecting their short\u2010term clinical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/wjs.12018","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T13:04:20Z","timestamp":1702991060000},"page":"86-96","source":"Crossref","is-referenced-by-count":5,"title":["Long term survival outcomes of surgery combined with hyperthermic intraperitoneal chemotherapy for perforated low\u2010grade appendiceal mucinous neoplasms: A\u00a0multicenter retrospective study"],"prefix":"10.1002","volume":"48","author":[{"given":"Zhenlong","family":"Han","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery The Affiliated Hospital of Qingdao University  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery The Affiliated Hospital of Qingdao University  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery The Affiliated Hospital of Qingdao University  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Weifang People's Hospital  Weifang Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery The People's Hospital of Jimo Qingdao  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuiqing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery The People's Hospital of Jimo Qingdao  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery The People's Hospital of Dongying Shandong  Dongying Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery The People's Hospital of Dongying Shandong  Dongying Shandong 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