{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:39:16Z","timestamp":1783633156655,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T00:00:00Z","timestamp":1702080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We analyze the long\u2010term outcome of surgery for Cushing's syndrome (CS) and the influence of the extent of surgical resection on the duration of postoperative cortisone substitution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One\u2010hundred forty\u2010one patients (129 female, 12 males; mean age: 45.7\u00a0\u00b1\u00a012.8\u00a0years) operated between January 2000 to June 2020 were included in the analysis. Patients suffered from manifest (124) or subclinical (17) CS due to benign unilateral adrenal neoplasia. All tumors were removed by the posterior retroperitoneoscopic approach. 105 patients had total (TA) and 36 partial (PA) adrenalectomies. All patients were discharged with ongoing corticosteroid supplementation therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Follow\u2010up data could be obtained for 83 patients. Twenty\u2010four (1\u00a0male, 23 females; mean age 42.3\u00a0years) underwent PA and 59\u00a0TA (6 males, 53 females; mean age 44.6\u00a0years). Mean follow\u2010up time was 107\u00a0\u00b1\u00a068\u00a0months (range: 6\u2013243\u00a0months). The median duration of postoperative corticosteroid therapy was 9.5\u00a0months after PA and 11\u00a0months after TA (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.1). Significantly, more patients after total adrenalectomy required corticosteroid therapy for more than 24\u00a0months (25% vs. 4%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03). Recurrent ipsilateral disease occurred in one case after partial adrenalectomy and was treated by completion adrenalectomy. A case of contralateral recurrence associated with subclinical Cushing's syndrome was observed after total adrenalectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The risk of local recurrence after partial adrenalectomy in CS is low. Cortical\u2010sparing surgery may shorten corticosteroid supplementation therapy after surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/wjs.12023","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T13:18:45Z","timestamp":1702991925000},"page":"121-129","source":"Crossref","is-referenced-by-count":7,"title":["Long\u2010term outcome of retroperitoneoscopic partial versus total adrenalectomy in patients with Cushing's syndrome"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8508-9934","authenticated-orcid":false,"given":"P. F.","family":"Alesina","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Chirurgie und Zentrum f\u00fcr Minimal Invasive Chirurgie Kliniken Essen\u2010Mitte  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Kniazeva","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Chirurgie und Zentrum f\u00fcr Minimal Invasive Chirurgie Kliniken Essen\u2010Mitte  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Chirurgie und Zentrum f\u00fcr Minimal Invasive Chirurgie Kliniken Essen\u2010Mitte  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pontin","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Chirurgie und Zentrum f\u00fcr Minimal Invasive Chirurgie Kliniken Essen\u2010Mitte  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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