{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T04:46:32Z","timestamp":1785041192909,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018049","name":"Hulda Almroth Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous reports have suggested higher rates of mortality and amputation for female patients in acute lower limb ischemia (ALI). The aims of the present study were to investigate if there is a difference in mortality, amputation, and fasciotomy between the sexes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study of consecutive patients undergoing index revascularization for ALI between 2001 and 2018 was conducted. A propensity score was created through a logistic regression with female\/male sex as an outcome. Cox regression analyses for 90\u2010day and 1\u2010year mortality, combining major amputation\/mortality, and logistic regression for major bleeding and fasciotomy, were performed. All analyses were performed with and without adjusting for propensity score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 709 patients were included in the study of which 45.9% were women. Mean age was 72.1\u00a0years. Females were older and had higher rates of atrial fibrillation, embolic disease, and lower estimated glomerular filtration rate, while men more often had anemia and chronic peripheral arterial disease. Mortality at 1\u00a0year was 21.2% for women and 14.7% for men. The adjusted hazard ratio for 1\u2010year mortality was 0.99 (95% CI 0.67\u20131.46). Fasciotomy was performed in 7.1% of female and 12.8% of male patients; the adjusted odds ratio was 0.52 (95% CI 0.29\u20130.91).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sex was not found to be an independent risk factor for mortality or combined major amputation\/mortality after revascularization for acute lower limb ischemia, whereas women had lower odds of undergoing fasciotomy. Whether women are underdiagnosed or do not develop acute compartment syndrome in the lower leg as often as men should be evaluated prospectively.<\/jats:p><\/jats:sec>","DOI":"10.1002\/wjs.12058","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T10:50:10Z","timestamp":1704192610000},"page":"746-755","source":"Crossref","is-referenced-by-count":3,"title":["Sex differences in outcomes after revascularization for acute lower limb ischemia: Propensity score adjusted analysis"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5894-1191","authenticated-orcid":false,"given":"Emil","family":"Karonen","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"},{"name":"Vascular Centre Department of Cardiothoracic and Vascular Surgery Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frida","family":"Eek","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talha","family":"Butt","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"},{"name":"Vascular Centre Department of Cardiothoracic and Vascular Surgery Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Acosta","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"},{"name":"Vascular Centre Department of Cardiothoracic and Vascular Surgery Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2019.09.006"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.01.053"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.08.064"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2021.10.044"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2016.03.023"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2022.02.007"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.11.057"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2021.662744"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010150\u20109\u2010200905050\u201000006"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0741\u20105214(97)70045\u20104"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","DOI":"10.1111\/j.1538-7836.2009.03678.x","article-title":"Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. 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