{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:30:36Z","timestamp":1789770636488,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pediatric endocrine disorders requiring surgical intervention are rare and so are experienced surgeons dealing with these. The aim of the current study was to investigate disease profile and perioperative outcome of pediatric patients with surgical endocrine disorders in an endocrine surgery unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study (Sep 1989\u2013Aug 2019) consisted of pediatric endocrine surgery patients (&lt;18\u00a0years) who were managed by a team of pediatric endocrinologists and endocrine surgeons at our center. Patients were divided into three cohorts consisting of a decade each. Clinico\u2010pathologic variables, perioperative events operative and follow\u2010up details were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 332 children were included and their mean age was 14.6\u00a0\u00b1\u00a03.9\u00a0years (M:<jats:italic>F<\/jats:italic>\u00a0=\u00a01:1.6). Thyroid disorders were most prevalent (59.8%), followed by adrenal (28.2%), parathyroid (10.4%), and pancreas (1.5%). Incidence of benign, malignant, and congenital\/developmental disorders were 65.4, 28.1 and 8.3, respectively. Familial association was observed in 8.9% children, which is highest among pheochromocytoma patients. Overall, 201 thyroidectomies\u00a0+\u00a0associated procedures, 35 parathyroidectomies, 96 adrenal and paraganglioma resections, and 5 pancreatic procedures were performed. Median hospital stay was 5.6\u00a0\u00b1\u00a04.1\u00a0days. The number of cases increased significantly over 3\u00a0decades. Clinical profile and outcome did not vary except for significant decrease in incidence of malignant pathology (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04) and increase in VHL cases (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04) in the last decade though overall increase in familial cases was nonsignificant (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.11). No perioperative mortality was observed except for 3% after adrenalectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A team of dedicated endocrine surgeons and pediatric endocrinologists is effective in management of pediatric endocrine surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/wjs.12075","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T05:40:29Z","timestamp":1706766029000},"page":"729-738","source":"Crossref","is-referenced-by-count":2,"title":["Clinico\u2010pathologic profile and outcomes of pediatric endocrine patients managed by endocrine surgeons: Experience over three decades in a tertiary center in India"],"prefix":"10.1002","volume":"48","author":[{"given":"Sharanappa","family":"Vikram","sequence":"first","affiliation":[{"name":"Department of Endocrine Surgery Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow 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