{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:48:00Z","timestamp":1791110880741,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Colorectal peritoneal metastases are a devastating consequence of colorectal cancer (CRC) with extremely poor prognosis. Patients that can undergo complete cytoreduction by cytoreductive surgery and heated intraperitoneal chemotherapy (CRS\/HIPEC) have a markedly improved overall survival. Traditionally, patients with extremely high peritoneal cancer index (PCI), PCI &gt;20, are not offered CRS\/HIPEC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective analysis of our prospectively maintained CRS\/HIPEC database and evaluated all patients with CRC peritoneal metastases between 2012 and 2022. We divided the cohorts between those with low operative PCI (PCI&lt;20) and high operative PCI (PCI =&gt;20). We examined demographic, clinicopathologic data, perioperative, and oncological outcomes between the cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 691 patients who underwent CRS\/HIPEC, 289 were evaluable with CRC metastases, 234 with PCI &lt;20 and 43 with PCI =&gt; 20. Median radiologic preoperative and operative PCI was 4 and 10 versus 7 and 24.5 in the low and high PCI cohorts, respectively. Operative time was longer (6 vs. 4\u00a0h) and blood loss higher (500 vs. 400\u00a0mL) in the high PCI cohort. All other demographic, clinicopathological, and operative characteristics were similar. Median disease free survival (DFS) was longer in the low PCI cohort (11.5 vs. 7\u00a0months) but overall survival (OS) showed benefit (41.3 vs. 31.8\u00a0months), (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001 and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.189, respectively), comparatively with an only chemotherapy strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Appropriately selected patients with CRC metastases and extremely high PCI demonstrate similar perioperative safety outcomes in experienced tertiary referral centers. Despite a shorter median DFS, these carefully selected patients demonstrated similar median OS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/wjs.12080","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T07:34:30Z","timestamp":1704872070000},"page":"871-878","source":"Crossref","is-referenced-by-count":4,"title":["Extremely high peritoneal cancer index in colorectal peritoneal metastases demonstrates safety and overall survival benefit in selected patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy"],"prefix":"10.1002","volume":"48","author":[{"given":"Almog","family":"Ben\u2010Yaacov","sequence":"first","affiliation":[{"name":"Department of General Surgery C and Surgical Oncology Sheba Medical Center  Ramat Gan Israel"},{"name":"Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Levine","sequence":"additional","affiliation":[{"name":"Department of General Surgery C and Surgical Oncology Sheba Medical Center  Ramat Gan Israel"},{"name":"Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gal","family":"Schtrechman","sequence":"additional","affiliation":[{"name":"Department of General Surgery C and Surgical Oncology Sheba Medical Center  Ramat Gan Israel"},{"name":"Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Adileh","sequence":"additional","affiliation":[{"name":"Department of General Surgery C and Surgical Oncology Sheba Medical Center  Ramat Gan Israel"},{"name":"Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Beller","sequence":"additional","affiliation":[{"name":"Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Department of Oncology Sheba Medical Center  Ramat Gan 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