{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:54:44Z","timestamp":1792122884711,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Peritoneal carcinomatosis is considered a late\u2010stage manifestation of neoplastic diseases. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS\u2010HIPEC) can be an effective treatment for these patients. However, the procedure is associated with significant morbidity. Our aim was to develop a machine learning model to predict the probability of achieving textbook outcome (TO) after CRS\u2010HIPEC using only preoperatively known variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult patients with peritoneal carcinomatosis and who underwent CRS\u2010HIPEC were included from a large, single\u2010center, prospectively maintained dataset (2001\u20132020). TO was defined as a hospital length of stay \u226414\u00a0days and no postoperative adverse events including any complications, reoperation, readmission, and mortality within 90\u00a0days. Four models (logistic regression, neural network, random forest, and XGBoost) were trained, validated, and a user\u2010friendly risk calculator was then developed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1954 CRS\u2010HIPEC procedures for peritoneal carcinomatosis were included. Overall, 13% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0258) achieved TO following CRS\u2010HIPEC procedure. XGBoost and logistic regression had the highest area under the curve (AUC) (0.76) after model optimization, followed by random forest (AUC 0.75) and neural network (AUC 0.74). The top preoperative variables associated with achieving a TO were lower peritoneal cancer index scores, not undergoing proctectomy, splenectomy, or partial colectomy and being asymptomatic from peritoneal metastases prior to surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is a data\u2010driven study to predict the probability of achieving TO after CRS\u2010HIPEC. The proposed pipeline has the potential to not only identify patients for whom surgery is not associated with prohibitive risk, but also aid surgeons in communicating this risk to patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/wjs.12184","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T13:08:25Z","timestamp":1713877705000},"page":"1404-1413","source":"Crossref","is-referenced-by-count":1,"title":["A machine learning approach for predicting textbook outcome after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2745-5032","authenticated-orcid":false,"given":"Amir","family":"Ashraf Ganjouei","sequence":"first","affiliation":[{"name":"Department of Surgery University of California  San Francisco California 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