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The PRISMA guidelines were adopted, and the Newcastle\u2010Ottawa Quality Assessment Scale used for risk of bias assessment. Outcomes on overall and organ\u2010specific MM were extracted. A narrative analysis followed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 2143 unique hits, 162 publications were read in full\u2010text and 37 population\u2010based cohort studies published in 1981\u20132022 were included. Ten studies adopted time\u2010dependent analyses; eight were registry\u2010based and seven had a low risk of bias. Three studies reported 5\u2010year recurrence rate of MM overall of stages I\u2013III; for CRC, it was 20.5%, for CC, it was 18% and 25.6%, and for RC, it was 23%. Four studies reported 5\u2010year recurrence rate of organ\u2010specific MM of stages I\u2013III\u2014for CRC, it was 2.2% and 5.5% for peritoneal metastases and 5.8% for lung metastases and for CC 4.5% for peritoneal metastases. Twenty\u2010seven studies reported proportions of patients diagnosed with MM, but data on the length of follow\u2010up was incomplete and varied widely. Proportions of patients with CRC stages I\u2013III that developed MM overall was 14.4%\u201326.1% in 10 studies. In relation to the enrollment period, a downward trend may be discernible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Studies adopting a more appropriate analysis were highly heterogeneous, whereas uncertain data of partly inadequate studies may indicate that MM are overall declining.<\/jats:p><\/jats:sec>","DOI":"10.1002\/wjs.12204","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T12:31:42Z","timestamp":1715776302000},"page":"1521-1533","source":"Crossref","is-referenced-by-count":2,"title":["A systematic review of population\u2010based studies on metachronous metastases of colorectal cancer"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7781-1624","authenticated-orcid":false,"given":"Karin","family":"Nystr\u00f6m","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"},{"name":"Department of Oncology \u00d6rebro University Hospital  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8708-7502","authenticated-orcid":false,"given":"Louise","family":"Olsson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"},{"name":"Centre for Assessment of Medical Technology \u00d6rebro University Hospital  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585\u2010015\u20109719\u20100"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.01.025"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20101318.2010.02539.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq227"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(18)30646\u20106"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000464358"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.14870"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186x.2015.1131331"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(19)30485\u20101"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13159"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(86)91510\u20102"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.20.6771"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(20)30527\u20101"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(20)30555\u20106"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20101253(22)00084\u2010x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2022.102184"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.06.022"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/dcr.0000000000001984"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002200.pub4"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2015.06.006"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199002083220602"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032709"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2019.101948"},{"key":"e_1_2_9_26_1","volume-title":"International prospective register of systematic reviews","author":"Prospero","year":"2022"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_28_1","unstructured":"Wells G. 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