{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:06:30Z","timestamp":1791612390089,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T00:00:00Z","timestamp":1716681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Post\u2010surgical hypoparathyroidism often occurs after total thyroidectomy (TT). The aim of this study is to investigate whether the use of near\u2010infrared autofluorescence (NIRAF) of parathyroid glands (PGs) can aid experienced surgeons in identifying more PGs during surgery, potentially reducing unintended resection, and assessing its impact on post\u2010surgical hypoparathyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>All patients undergoing at least a TT by two experienced surgeons, between 2020 and 2021, were enrolled and randomized into two cohorts: NIRAF group (NG) and CONTROL group (CG). Transient hypoparathyroidism was defined by serum concentration of PTH&lt;12\u00a0ng\/mL at the 1st post\u2010operative day and permanent by the need of calcium\u2010active vitamin D treatment &gt;6\u00a0months from the surgery with still undetectable PTH or &lt;12\u00a0ng\/m.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 236 patients (111 in NG, 125 in CG), the number of PGs identified was higher in NG (93.9%, 417\/444) compared to CG (81.4%, 407\/500) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), with a mean of 3.76\u00a0\u00b1\u00a00.44 PGs per patient in NG and 3.25\u00a0\u00b1\u00a00.79 in CG. The number of unintendedly resected PGs was 14 in NG and 42 in CG (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Transient hypoparathyroidism was observed in 18 patients (16.2%) in NG and 40 patients (32.0%) in CG (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.004). Permanent hypoparathyroidism affected 1 patient in NG and 7 patients in CG (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.06). The mean operative time was longer in NG (104.3\u00a0\u00b1\u00a032.08\u00a0min) compared to CG (85.5\u00a0\u00b1\u00a040.62\u00a0min) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NIRAF enhances the identification of PGs, preventing their inadvertent resection and reducing the overall incidence of post\u2010surgical hypoparathyroidism.<\/jats:p><\/jats:sec>","DOI":"10.1002\/wjs.12236","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T05:23:21Z","timestamp":1716787401000},"page":"1710-1720","source":"Crossref","is-referenced-by-count":12,"title":["Impact of autofluorescence\u2010guided surgery of parathyroid glands during total thyroidectomy in experienced surgeons: A randomized clinical trial"],"prefix":"10.1002","volume":"48","author":[{"given":"Jose Luis","family":"Carrillo Lizarazo","sequence":"first","affiliation":[{"name":"General and Endocrine Surgery CHU Poitiers\u2014University of Poitiers  Poitiers France"},{"name":"General and Endocrine Surgery University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohail","family":"Bakkar","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Department Hashemite University  Zarqa Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Zerrweck","sequence":"additional","affiliation":[{"name":"Metabolic and Endocrine Surgery ABC Hospital  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1924-8848","authenticated-orcid":false,"given":"Marcos Martin","family":"Onofre Ramos","sequence":"additional","affiliation":[{"name":"\u00c9cole Nationale Sup\u00e9rieure de M\u00e9canique et d'A\u00e9rotechnique\u2010 Poitiers  Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Louis","family":"Kraimps","sequence":"additional","affiliation":[{"name":"General and Endocrine Surgery CHU Poitiers\u2014University of Poitiers  Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6031-9115","authenticated-orcid":false,"given":"Gianluca","family":"Donatini","sequence":"additional","affiliation":[{"name":"General and Endocrine Surgery CHU Poitiers\u2014University of Poitiers  Poitiers France"},{"name":"Unit\u00e9 INSERM U1313\u2010 IRMETIST  Poitiers 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