{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T04:10:12Z","timestamp":1759896612964,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The United Kingdom Registry of Endocrine and Thyroid Surgery (UKRETS) holds the largest database of pediatric parathyroidectomy cases globally. There are currently no quoted acceptable cure or complication rates in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective database analysis evaluates the efficacy and safety of targeted parathyroidectomy (tPTx) and bilateral neck exploration (BNE) in first\u2010time parathyroidectomy for pediatric primary hyperparathyroidism (PHPT) through analysis of the UKRETS database (1995\u20132022). Pre\u2010, intra\u2010 and postoperative outcomes were assessed and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>168 cases underwent parathyroidectomy; 25 (15%) familial and 143 (85%) sporadic PHPT. 69% were female with a mean age of 10\u00a0years (Range 0\u201317). BNE was the most common operative approach (61%; <jats:italic>n<\/jats:italic>\u00a0=\u00a0103\/168). The most frequently used imaging modality was US (80%; <jats:italic>n<\/jats:italic>\u00a0=\u00a0135\/168). Mean number of glands excised in familial cases was three compared to one gland in sporadic cases (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Familial cases had a significantly higher rate of postoperative hypocalcemia (32% vs. 9%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) and all were BNE. Cure rate was 96.9% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0127\/131), with differences in cure rates that did not reach statistical significance (sporadic 98.2% vs. familial 90.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.06). Preoperative localization (image\u2010positive or negative) made no difference to cure rates in either familial (90% vs. 91%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.94) or sporadic (97.5% vs. 100%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.4) cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This analysis demonstrates that first\u2010time pediatric parathyroidectomy for PHPT is safe and effective. Familial cases have a higher rate of postoperative hypocalcemia; therefore, parents should be informed of this when consented. Targeted parathyroidectomy is safe and effective in both sporadic and familial cases, as long as there is positive preoperative imaging.<\/jats:p><\/jats:sec>","DOI":"10.1002\/wjs.12329","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T10:18:46Z","timestamp":1726741126000},"page":"2463-2470","source":"Crossref","is-referenced-by-count":1,"title":["A retrospective database analysis of pediatric parathyroidectomies from the United Kingdom registry of endocrine and Thyroid Surgeons"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5805-8155","authenticated-orcid":false,"given":"Ysabelle","family":"Embury\u2010Young","sequence":"first","affiliation":[{"name":"Gloucester Royal Hospital ENT Department Gloucestershire Hospitals NHS Foundation Trust  Gloucester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4722-0747","authenticated-orcid":false,"given":"Laura","family":"Brennan","sequence":"additional","affiliation":[{"name":"Bristol Royal Infirmary ENT Department University Hospital Bristol and Weston NHS Trust  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Jackson","sequence":"additional","affiliation":[{"name":"Bristol Royal Infirmary ENT Department University Hospital Bristol and Weston NHS Trust  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Aspinall","sequence":"additional","affiliation":[{"name":"Aberdeen Royal Infirmary General Surgery Department NHS Grampian  Aberdeen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Stechman","sequence":"additional","affiliation":[{"name":"University Hospital Wales General Surgery Department Cardiff and Vale University Health Board  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabapathy","family":"Balasubramanian","sequence":"additional","affiliation":[{"name":"Sheffield Teaching Hospitals NHS Foundation Trust General Surgery Department  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae","family":"Kim","sequence":"additional","affiliation":[{"name":"Royal Marsden Hospital ENT Department  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiro","family":"Ishii","sequence":"additional","affiliation":[{"name":"Bristol Royal Infirmary ENT Department University Hospital Bristol and Weston NHS Trust  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"AspinallS. 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