{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:36:30Z","timestamp":1788280590170,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The potential benefit of intraoperative wound irrigation (IOWI) in preventing surgical site infection (SSI) remains unclear. The use of antimicrobial agents (AMA) or antiseptic agents (ASA) is controversial worldwide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a systematic review and meta\u2010analysis of randomized clinical trials comparing AMA or ASA with saline solution in patients who underwent abdominal surgery. Sub\u2010analyses were performed on the type of surgery, type of intervention agent, and wound classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen studies comprising 4915 patients undergoing abdominal surgery were included. SSI was observed in 207 out of 2504 patients in the intervention group (8.26 %) and 344 out of 2411 patients in the control group (14.27%). Overall, intraoperative wound irrigation (IOWI) with AMA or ASA was associated with a lower SSI (Odds ratio (OR) 0.62; 95% CI 0.47, 0.82; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a050%). Sub\u2010analyses have shown a tendency for decreased SSI in patients from emergency surgery (OR 0.46; 95% CI 0.30, 0.70; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a023%), patients with contaminated wound (OR 0.48; 95% CI 0.31, 0.74; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a024%), and either the use of AMA or ASA (OR 0.53 vs. 0.65).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The overall use of AMA or ASA before skin closure was associated with decreased SSI. Lower rates of SSI were observed in the subgroup analysis. Furthermore, we must consider the critical heterogeneity of the studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/wjs.12339","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T22:30:29Z","timestamp":1726093829000},"page":"2400-2412","source":"Crossref","is-referenced-by-count":5,"title":["Intraoperative wound irrigation to prevent surgical site infection: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4666-502X","authenticated-orcid":false,"given":"Kaique Flavio Xavier Cardoso","family":"Filardi","sequence":"first","affiliation":[{"name":"Department of Surgery Division of Digestive Surgery University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Roberto Minetto","family":"Wegner","sequence":"additional","affiliation":[{"name":"Universidade Federal da Fronteira do Sul  Chapeco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaldo Bastos","family":"dos Santos","sequence":"additional","affiliation":[{"name":"S\u00edrio Liban\u00eas Hospital  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela Goes Machado","family":"Filardi","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Ferreira","family":"Vasques","sequence":"additional","affiliation":[{"name":"University Catholic of Pelotas  Pelotas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia Cardoso","family":"Massoni","sequence":"additional","affiliation":[{"name":"Bahiana School of Medicine and Public Health  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena Poliana Chimanski","family":"Da Costa","sequence":"additional","affiliation":[{"name":"University Center Assis Gurgacz Foundation  Cascavel Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2023.67"},{"key":"e_1_2_11_3_1","first-page":"59","volume-title":"Journal of the American College of Surgeons","author":"Ban K. 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