{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:36:12Z","timestamp":1791894972608,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to conduct a retrospective study to identify inflammatory biomarkers for predicting ventilator\u2010associated pneumonia in elderly patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our retrospective study included 265 elderly patients (age \u226560\u00a0years) undergoing abdominal surgery with tracheal intubation and general anesthesia, with 93 experiencing varying degrees of ventilator\u2010associated pneumonia during hospitalization, and 172 without. Serum concentrations of serum amyloid A (SAA), toll\u2010like receptor 4 (TLR4), and soluble myeloid triggering receptor 1 (sTREM\u20101) were measured at 24\u00a0h post\u2010operation using enzyme\u2010linked immunosorbent assay. Comparisons of SAA, TLR4, and sTREM\u20101 and other risk factors at 24\u00a0h post\u2010operation between elderly patients with and without ventilator\u2010associated pneumonia were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study revealed a 35.1% incidence of postoperative ventilator\u2010associated pneumonia among elderly patients. Upregulations of SAA, TLR4, and sTREM\u20101 were observed in patients with ventilator\u2010associated pneumonia. Chronic obstructive pulmonary disease, smoking, and tracheal intubation were identified as independent risk factors. The joint prediction model was demonstrated with superior predictive accuracy (area under the curve\u00a0=\u00a00.89) compared to individual biomarkers. Correlations with procalcitonin further supported the predictive potential of SAA, TLR4, and sTREM\u20101 in an inflammatory response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SAA, TLR4, and sTREM\u20101, particularly when combined, serve as valuable prognostic indicators for postoperative ventilator\u2010associated pneumonia in elderly patients undergoing abdominal surgery with tracheal intubation and general anesthesia. The joint prediction model offered a promising tool for early risk assessment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/wjs.12343","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T10:09:06Z","timestamp":1726740546000},"page":"2383-2390","source":"Crossref","is-referenced-by-count":5,"title":["Predictive values of serum amyloid A, toll\u2010like receptor 4, and sTREM\u20101 for ventilator\u2010associated pneumonia in elderly patients undergoing abdominal surgery with tracheal intubation and general anesthesia"],"prefix":"10.1002","volume":"48","author":[{"given":"Jianchuan","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Quanzhou First Hospital Affiliated to Fujian Medical University  Quanzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenming","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Quanzhou First Hospital Affiliated to Fujian Medical University  Quanzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Quanzhou First Hospital Affiliated to Fujian Medical University  Quanzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxuan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology the Third People Hospital of Chengdu  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5519-3004","authenticated-orcid":false,"given":"Shunyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Quanzhou First Hospital Affiliated to Fujian Medical University  Quanzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnma.2023.09.002"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2019.11.021"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf03018895"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000207097.38963.3b"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605211043245"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzx018"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2022.06.017"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2023.113574"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1638\/2016\u20100267.1"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201046266\u2010x"},{"key":"e_1_2_12_12_1","first-page":"67","article-title":"Effects of Piperlonguminine on Lung Injury in Severe Acute Pancreatitis <em>via<\/em> the TLR4\/NF\u2010kappaB Pathway Eur","author":"Hu Q.","year":"2023","journal-title":"J. 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