{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:24:55Z","timestamp":1783488295237,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015077","name":"Wydzia\u0142 Lekarski, Uniwersytet Jagiello\u0144ski Collegium Medicum","doi-asserted-by":"publisher","award":["N41\/DBS\/001266"],"award-info":[{"award-number":["N41\/DBS\/001266"]}],"id":[{"id":"10.13039\/100015077","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to validate in 20\u2010year follow\u2010up (FU) the outcomes reported in World J Surg 2010; 34(6):1232\u20138 on recurrent nodular goiter in the contralateral thyroid lobe among patients after thyroid lobectomy (TL) for multinodular goiter (MNG) receiving versus not receiving postoperative prophylactic levothyroxine (LT4) treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Some 150 consenting patients underwent TL for MNG in 2000\u20132003. They were randomized to two groups, 75 patients each: (a) receiving prophylactic LT4 treatment postoperatively (dose range 75\u2013125 microg\/day to maintain thyroid\u2010stimulating hormone values within 0.27\u20131.0\u00a0mU\/L), and (b) not receiving LT4. Sixty\u2010month FU was extended to 240\u00a0months for all the consenting patients. The primary outcome was prevalence of recurrent goiter. The secondary outcome was re\u2010intervention rate for recurrent goiter. The outcomes were stratified according to individual iodine metabolism status assessed by urinary iodine excretion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the 5\u2010year FU (5 patients were lost) recurrent goiter was found in patients receiving versus not receiving LT4 in 1.4% versus 16.7% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) whereas during 20\u2010year FU (29 patients were lost) it was 3.3% versus 30.0% of patients, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.031). During 20\u2010year FU 4.9% versus 30.0%, respectively, of patients receiving versus not receiving LT4 required contralateral thyroid lobe treatment\/surgery (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.028). LT4 decreased recurrence rate among iodine\u2010deficient patients (10.0% vs. 70.0%, respectively; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.037) but not among iodine\u2010sufficient patients (0.0% vs. 10.0%, respectively; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.056).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Twenty\u2010year FU data confirmed that prophylactic LT4 treatment significantly decreased the recurrence of nodular goiter and the need for completion intervention\/surgery, mostly among patients with iodine deficiency.<\/jats:p><\/jats:sec>","DOI":"10.1002\/wjs.12403","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T22:43:48Z","timestamp":1731710628000},"page":"140-147","source":"Crossref","is-referenced-by-count":2,"title":["Twenty\u2010year follow\u2010up of a randomized clinical trial of unilateral thyroid lobectomy with or without postoperative levothyroxine treatment"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6062-1851","authenticated-orcid":false,"given":"Marcin","family":"Barczy\u0144ski","sequence":"first","affiliation":[{"name":"Department of Endocrine Surgery Faculty of Medicine Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0311-8157","authenticated-orcid":false,"given":"Filip","family":"Go\u0142kowski","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine Faculty of Medicine Andrzej Frycz Modrzewski Krakow University  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5208-4689","authenticated-orcid":false,"given":"Alicja","family":"Hubalewska\u2010Dydejczyk","sequence":"additional","affiliation":[{"name":"Chair and Department of Endocrinology Faculty of Medicine Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8103-4082","authenticated-orcid":false,"given":"Aleksander","family":"Konturek","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Faculty of Medicine Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2019.06.004"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.04.045"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010008\u20109477\u20100"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.05.003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0b013e3182360118"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010010\u20100439\u2010y"},{"key":"e_1_2_10_8_1","first-page":"1097","article-title":"Prospective, Randomized, Double\u2010Blind Study about Effectiveness of Levothyroxine Suppressive Therapy in Prevention of Recurrence after Operation: Result at the Third Year of Follow up","volume":"114","author":"Miccoli 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