{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:40:04Z","timestamp":1791603604696,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Active surveillance (AS) for low\u2010risk papillary thyroid carcinoma (PTC) is acknowledged as a valid management strategy. While older age is identified as a favorable factor for progression, long\u2010term evidence is scarce and lifelong monitoring has been deemed essential. This study investigated progression patterns and tumor calcification under long\u2010term AS and explored the possibility of ending follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 650 patients with low\u2010risk PTC who chose AS were enrolled. Progression was defined as either tumor enlargement (\u22653\u00a0mm from initiation) or development of clinically apparent lymph node metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median observation period was 8\u00a0years; 45.2% were under surveillance for \u226510\u00a0years. Overall, 80 patients (12.3%) exhibited progression. Median age and observation period at the time of progression were 55 and 4\u00a0years, respectively. Only 2 patients showed progression after 15\u00a0years of follow\u2010up and 5 patients showed progression after reaching 80\u00a0years old. Among 71 patients experiencing tumor enlargement, surgery was performed immediately in 32 patients. The remaining 39 patients continued surveillance, but only 5 demonstrated ongoing enlargement thereafter. Of 40 surgeries due to progression, 36 were conducted within the first 10\u00a0years. The degree of calcification correlated with age and observation periods. No progression occurred after the development of rim calcification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Progression during AS was extremely rare in older patients with long\u2010term surveillance and in tumors with rim calcification. It may be feasible to consider ending scheduled surveillance visits for these patients. Instances of progression halting after enlargement are not uncommon.<\/jats:p><\/jats:sec>","DOI":"10.1002\/wjs.12417","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T22:35:23Z","timestamp":1732660523000},"page":"159-169","source":"Crossref","is-referenced-by-count":11,"title":["Long\u2010term outcomes of active surveillance for low\u2010risk papillary thyroid carcinoma: Progression patterns and tumor calcification"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5560-0706","authenticated-orcid":false,"given":"Iwao","family":"Sugitani","sequence":"first","affiliation":[{"name":"Department of Endocrine Surgery Nippon Medical School  Tokyo Japan"},{"name":"Division of Head and Neck Cancer Institute Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuta","family":"Nagaoka","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Nippon Medical School  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