{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:56:12Z","timestamp":1786978572333,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K07013"],"award-info":[{"award-number":["22K07013"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pathological regression grade after chemotherapy evaluated by surgically resected specimens is closely related with prognosis. Since usefulness of measuring the area of the residual tumor (ART) has been reported, this study aimed to evaluate the utility of ART in predicting the prognosis of patients with gastric cancer (GC) who received preoperative chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This single\u2010center retrospective study examined the relationship between ART and survival outcomes. We included 92 patients who underwent preoperative chemotherapy followed by radical surgery for GC. Digital images were used to measure the ART in the largest pathological slice of each patient's surgical tumor specimen. We simply subclassified the patients as either ART\u20100 (&lt;\u00a00.1\u00a0mm\n                      <jats:sup>2<\/jats:sup>\n                      or carcinoma in situ) or non\u2010ART\u20100 to compare the prognoses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant differences were noted in overall survival and recurrence\u2010free survival (RFS) between ART\u20100 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a019) and non\u2010ART\u20100 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a073). The survival curves were similar to those of major pathological response (MPR) (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a024) or non\u2010MPR (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a068), which are commonly used as surrogate endpoint presently. Multivariate analysis revealed ART and ypN independent prognostic factors for RFS. Survival curves stratified using ART and ypN to indicate risk grades (low\u2010, moderate\u2010, or high\u2010) were not significantly different from those stratified using the other three existing pathological regression grade systems and ypN.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ART\u2010based pathological assessment is a simple and useful method for predicting the prognosis in patients with GC who underwent radical surgery after chemotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.12482","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T23:19:24Z","timestamp":1736896764000},"page":"717-726","source":"Crossref","is-referenced-by-count":1,"title":["Area of Residual Tumor Measurement After Preoperative Chemotherapy as an Objective and Quantitative Method for Predicting the Prognosis of Gastric Cancer: A Single\u2010Center Retrospective Study"],"prefix":"10.1002","volume":"49","author":[{"given":"Hiromi","family":"Nagata","sequence":"first","affiliation":[{"name":"Department of Pathology and Clinical Laboratories National Cancer Center Hospital East  Kashiwa Japan"},{"name":"Division of Gastric Surgery National Cancer Center Hospital East  Kashiwa Japan"},{"name":"Course of Advanced Clinical Research of Cancer Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Division of Gastric Surgery National Cancer Center Hospital East  Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Sakashita","sequence":"additional","affiliation":[{"name":"Division of Pathology Exploratory Oncology Research &amp; Clinical Trial Center National Cancer Center  Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiro","family":"Kojima","sequence":"additional","affiliation":[{"name":"Division of Pathology Exploratory Oncology Research &amp; Clinical Trial Center National Cancer Center  Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Taki","sequence":"additional","affiliation":[{"name":"Department of Pathology and Clinical Laboratories National Cancer Center Hospital East  Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kuwata","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine and Services National Cancer Center Hospital East  Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yura","sequence":"additional","affiliation":[{"name":"Division of Gastric Surgery National Cancer Center Hospital East  Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Shitara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Gastrointestinal Oncology National Cancer Center Hospital East  Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genichiro","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Pathology and Clinical Laboratories National Cancer Center Hospital East  Kashiwa Japan"},{"name":"Course of Advanced Clinical Research of Cancer Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6273-0189","authenticated-orcid":false,"given":"Naoya","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Division of Pathology Exploratory Oncology Research &amp; Clinical Trial Center National Cancer Center  Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13521"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101827.2009.02464.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181c0a1f8"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201053801\u20102"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15273"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02914"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120\u2010022\u201001331\u20108"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2023.102226"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00797\u20102"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)32557\u20101"},{"key":"e_1_2_12_13_1","volume-title":"Japanese Classification of Gastric Carcinoma","author":"Japanese Gastric Cancer Association","year":"2017"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19940601)73:11<2680::aid\u2010cncr2820731105>3.0.co;2\u2010c"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11660"},{"key":"e_1_2_12_16_1","unstructured":"N.Shaili Aggarwal L.Hang N.McMillian et\u00a0al. NCCN Guidelines Version 2.2023 Gastric Cancer Continue NCCN Guidelines Panel Disclosures (2023) https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/gastric.pdf."},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10120\u2010014\u20100401\u2010Z"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15143662"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181e4585e"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199810000\u201000002"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957\u2010022\u201002725\u20109"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120\u2010017\u20100701\u20101"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5921"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjs.12482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T14:41:25Z","timestamp":1744382485000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/wjs.12482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,14]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/wjs.12482"],"URL":"https:\/\/doi.org\/10.1002\/wjs.12482","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,14]]}}}