{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T10:36:49Z","timestamp":1771929409802,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aims conventional bowel preparation restricts dietary intake up to 72\u00a0h prior to colonoscopy. Bowel preparation process is often perceived as unpleasant leading to poor compliance and subsequent poor bowel preparation. The aim of this trial is to compare the efficacy of low\u2010residue semi\u2010elemental enteral formula (LREF) incorporated diet versus the standard diet in polyethylene glycol (PEG)\u2010based bowel preparation in the aim of creating a more tolerable bowel preparation regimen without compromising bowel cleanliness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a multicenter, prospective, single\u2010blinded, randomized controlled noninferiority trial. The noninferiority margin was set at 15%. One hundred sixty\u2010seven patients were recruited and randomized to either the LREF group or the standard diet (SD) group using a 3L PEG preparation regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The LREF group results in comparable satisfactory preparation rating to the standard diet group with a mean BPPS score of 6.87 (SD 1.59) versus 7.14 (SD 1.54) (95% CI[\u22120.86; 0.32] and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.367). The mean difference (MD) of the BBPS total score between the two groups was \u22120.27 (95% CI [\u22120.764 and 0.224]). Equivalence were demonstrated using the two one\u2010sided test (alpha\u00a0=\u00a05%) with the lower t\u2010value of 2.682 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0042) and the upper t\u2010value of \u22124.493 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). There was also no significant difference in PEG compliance, willingness to repeat the procedure and tolerance to the bowel preparation between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The LREF incorporated diet is equivalent to regimen in achieving satisfactory bowel cleanliness in patients undergoing PEG\u2010based bowel preparation. We suggest that a LREF incorporated regimen for bowel preparation can be considered in patients who are unable to sustain prolonged fasting to improve the procedural experience.<\/jats:p><\/jats:sec>","DOI":"10.1002\/wjs.12490","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T03:06:00Z","timestamp":1737601560000},"page":"576-583","source":"Crossref","is-referenced-by-count":1,"title":["Adding Semi Elemental Enteral Nutrition Formula Improves Tolerance Without Compromising Bowel Preparation Quality for Colonoscopy: A Non\u2010Inferiority Randomized Controlled Trial"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6129-3786","authenticated-orcid":false,"given":"Nabil","family":"Mohammad Azmi","sequence":"first","affiliation":[{"name":"Colorectal Unit Department of Surgery Faculty of Medicine The National University of Malaysia  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4443-4359","authenticated-orcid":false,"given":"Anith","family":"Nadzira","sequence":"additional","affiliation":[{"name":"Colorectal Unit Department of Surgery Faculty of Medicine The National University of Malaysia  Kuala Lumpur Malaysia"},{"name":"Department of Surgery Hospital Kuala Lumpur  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nur Afdzillah","family":"Abdul Rahman","sequence":"additional","affiliation":[{"name":"Colorectal Unit Department of Surgery Faculty of Medicine The National University of Malaysia  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zairul Azwan","family":"Mohd Azman","sequence":"additional","affiliation":[{"name":"Colorectal Unit Department of Surgery Faculty of Medicine The National University of Malaysia  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soma Balaganapati","family":"Chandrakanthan","sequence":"additional","affiliation":[{"name":"Colorectal Unit Department of Surgery Faculty of Medicine The National University of Malaysia  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Melissa","family":"Dualim","sequence":"additional","affiliation":[{"name":"Colorectal Unit Department of Surgery Faculty of Medicine The National University of Malaysia  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Sagap","sequence":"additional","affiliation":[{"name":"Colorectal Unit Department of Surgery Faculty of Medicine The National University of Malaysia  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/dcr.0b013e3181fb1e52"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2013.7.6.681"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353244"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2013.01.046"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100029\u20101244236"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.20524\/aog.2016.0005"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00182"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40271\u2010015\u20100154\u20108"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/201010581202100304"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcol.2018.10.003"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.17235\/reed.2018.5140\/2017"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/mcg.0b013e3181662442"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109270(01)02437\u20106"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.09.066"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/ceor.s155312"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.05.057"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2020.21.5.1253"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2010.01.021"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2012.03.168"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjs.12490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T18:41:37Z","timestamp":1744396897000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/wjs.12490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,22]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/wjs.12490"],"URL":"https:\/\/doi.org\/10.1002\/wjs.12490","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,22]]}}}