{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:58:22Z","timestamp":1786978702526,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pancreatic fat accumulation, that is, fatty pancreas (FP), has gained attention because it contributes to pancreatic carcinogenesis. However, the impact of FP on the survival of patients with pancreatic cancer has not yet been elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Overall, 87 consecutive patients who were pathologically diagnosed with pancreatic ductal adenocarcinoma and underwent potentially curative pancreatectomy were eligible for analysis. Histological pancreatic fat fraction (HPFF) was evaluated using hematoxylin &amp; eosin\u2010stained slides of tumor and non\u2010tumor sections of the resected specimen, and quantified using imaging analysis software. The optimal HPFF value threshold for FP presence was determined using receiver operating characteristics curve analysis. The prognostic significance of FP was identified by a Cox proportional hazard model adjusted for the established prognostic covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fat accumulation within the invasive tumor front was scarce, with the median value for HPFF being 10.1% in the non\u2010tumor portion (range: 2.2%\u201345.8%). Patients with FP (HPFF value\u00a0\u2265\u00a011.3%) in the non\u2010tumor portion had significantly inferior overall survival (OS) and recurrence\u2010free survival (RFS) than those without FP (HPFF value\u00a0&lt;\u00a011.3%) (log\u2010rank test:\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.012 and\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.00060, respectively). In the multivariate analyses, the presence of FP emerged as an independent inferior prognostic indicator (OS: hazard ratio [HR] 2.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0015; PFS: HR 2.33,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.00080), together with lymph node metastases, presence of lymphatic involvement, and absence of adjuvant chemotherapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The present study indicates a possible prognostic role for pancreatic fat accumulation in patients with pancreatic adenocarcinoma.<\/jats:p>\n                  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