{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:16:44Z","timestamp":1788513404552,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Spontaneous retroperitoneal hematoma (SRPHs) is a serious disorder infrequently reported in the literature. Our aim was to analyze the clinical profile and management of a series of cases and to determine mortality predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied the consecutive series of patients with a SRPH at a university hospital from 2008 to 2023. Collected variables included clinical, physiological, and analytical characteristics as well as treatments provided. A modified Acute Physiology and Chronic Health Disease Classification System II (m\u2010APACHE II) and Charlson scores were calculated. The association of these factors with mortality during hospital admission and follow\u2010up were evaluated with logistic and Cox regression, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighty\u2010five patients with SRPH (mean age 75\u00a0years, 62.4% males) were identified. Of these, 56 (65.9%) were admitted for reasons other than SRPH, 67 (78.8%) received anticoagulants, and 53 (62.4%) had active bleeding on a CT scan. Seven patients were treated with palliative care. In the remaining 78 patients, management included transfusion (71 cases, 91%), anticoagulation reversal (25 cases, 32.1%), vasoactive drugs (21 cases, 26.9%), and admission to intermediate or critical care units (40 cases, 51.3%). Angiography was indicated in 34 (43.6%) patients, including embolization in 30 of these cases. Surgical drainage was required in two cases. Nineteen patients (24.5%) died during admission. m\u2010APACHE II score (OR\u00a0=\u00a01.21; 1.08\u20131.36) was a predictive factor. One\u2010 and 5\u2010year survival rates among hospital survivors were 68.4% and 29.2%, respectively. Survival was independently associated with the Charlson Comorbidity Index score (HR\u00a0=\u00a01.36; 1.14\u20131.63) and polypharmacy (HR\u00a0=\u00a01.13; 1.02\u20131.24).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SRPH is a serious disorder that requires complex therapeutic measures (critical care and angiography) in about half of patients. Several well\u2010known scores are good predictors of mortality and could be useful in clinical decision\u2010making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.12642","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T23:39:06Z","timestamp":1748475546000},"page":"1769-1776","source":"Crossref","is-referenced-by-count":2,"title":["Spontaneous Retroperitoneal Hematoma: Clinical Profile and Predictors of Mortality"],"prefix":"10.1002","volume":"49","author":[{"given":"Marta","family":"Durante","sequence":"first","affiliation":[{"name":"Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Department of Vascular and Endovascular Surgery Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2897-9295","authenticated-orcid":false,"given":"Maria","family":"Mascaro","sequence":"additional","affiliation":[{"name":"Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Department of Vascular and Endovascular Surgery Hospital del Mar  Barcelona Spain"},{"name":"Department of Medicine and Health Sciences Universitat Pompeu Fabra  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Calsina","sequence":"additional","affiliation":[{"name":"Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Department of Vascular and Endovascular Surgery Hospital del Mar  Barcelona Spain"},{"name":"Department of Medicine and Health Sciences Universitat Pompeu Fabra  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Velescu","sequence":"additional","affiliation":[{"name":"Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Department of Vascular and Endovascular Surgery Hospital del Mar  Barcelona Spain"},{"name":"Department of Medicine and Health Sciences Universitat Pompeu Fabra  Barcelona Spain"},{"name":"CIBER Cardiovascular Hospital del Mar Research Institute  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan Ramon","family":"Masclans","sequence":"additional","affiliation":[{"name":"Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Department of Medicine and Health Sciences Universitat Pompeu Fabra  Barcelona Spain"},{"name":"Department of Critical Care Hospital del Mar  Barcelona Spain"},{"name":"GREPAC Hospital del Mar Research Institute  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Clara","sequence":"additional","affiliation":[{"name":"Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Department of Vascular and Endovascular Surgery Hospital del Mar  Barcelona Spain"},{"name":"Department of Medicine and Health Sciences Universitat Pompeu Fabra  Barcelona Spain"},{"name":"CIBER Cardiovascular Hospital del Mar Research Institute  Barcelona 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