{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T03:49:41Z","timestamp":1775706581781,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The tall cell variant of papillary thyroid carcinoma (TCV\u2010PTC) is recognized as an aggressive subtype, yet its prognostic value independent of clinicopathological and molecular factors remains controversial, particularly in non\u2010Western populations. We aimed to evaluate the impact of TCV histology on disease\u2010free survival (DFS) in a large Middle Eastern cohort of patients with PTC undergoing standard surgical treatment and adjuvant radioactive iodine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study included 1065 patients with TCV\u2010PTC (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0174) or classical variant PTC (CV\u2010PTC;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0891) treated at a single tertiary center. A 1:3 propensity score matching (PSM) was performed to balance age, sex, tumor stage, lymph node status, and extrathyroidal extension. Logistic regression was used to assess independent predictors of persistent or recurrent disease. Kaplan\u2013Meier analysis evaluated disease\u2010free survival (DFS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After PSM, 174 TCV\u2010PTC cases were compared with 522 matched CV\u2010PTC cases. TCV\u2010PTC was associated with a higher rate of persistent\/recurrent disease (42.0% vs. 31.4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0119) and shorter 5\u2010year DFS (48.5% vs. 73.1%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001). On multivariate analysis, TCV histology remained an independent predictor of recurrence (OR\u00a0=\u00a02.09; 95% CI, 1.28\u20133.40;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0031), along with age \u2265\u00a055, extrathyroidal extension, nodal metastases, advanced T stage, and TERT promoter mutations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TCV\u2010PTC is independently associated with increased risk of disease persistence or recurrence following surgery. These findings support histological subtyping as a critical component of risk stratification and long\u2010term surveillance planning in patients with PTC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.12683","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T05:04:11Z","timestamp":1753506251000},"page":"2443-2448","source":"Crossref","is-referenced-by-count":3,"title":["Tall Cell Variant Histology Predicts Poorer Disease\u2010Free Survival in Papillary Thyroid Carcinoma: A Propensity\u2010Matched Cohort Study"],"prefix":"10.1002","volume":"49","author":[{"given":"Sandeep Kumar","family":"Parvathareddy","sequence":"first","affiliation":[{"name":"Human Cancer Genomic Research, Research Centre King Faisal Specialist Hospital and Research Centre  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul K.","family":"Siraj","sequence":"additional","affiliation":[{"name":"Human Cancer Genomic Research, Research Centre King Faisal Specialist Hospital and Research Centre  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeeshan","family":"Qadri","sequence":"additional","affiliation":[{"name":"Human Cancer Genomic Research, Research Centre King Faisal Specialist Hospital and Research Centre  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha","family":"Al\u2010Rasheed","sequence":"additional","affiliation":[{"name":"Human Cancer Genomic Research, Research Centre King Faisal Specialist Hospital and Research Centre  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael","family":"Haqawi","sequence":"additional","affiliation":[{"name":"Human Cancer Genomic Research, Research Centre King Faisal Specialist Hospital and Research Centre  Riyadh Saudi 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