{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:57:47Z","timestamp":1786978667196,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010629","name":"Fulbright Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010629","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Solomon Islands is a Western Pacific nation with one of the highest diabetes prevalences in the world. The delivery of surgical care is challenging given the country's complex geography and limited healthcare resources. This retrospective study aims to quantify diabetes\u2010associated major limb amputation and to describe the characteristics of patients undergoing this procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Demographic, clinical, and surgical data were abstracted for patients who underwent major limb amputation secondary to diabetic infection. Summary statistics were gathered from this dataset. Additionally, patients'\u00a0village names were abstracted, located from publicly available data, and mapped using ArcPro software. The geodesic distance between villages and the surgical centers performing amputation was calculated. Univariate and multivariate modeling was employed to assess the relationship between an a priori set of variables and several outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over a 5\u2010year period (2018\u20132023), 401 amputations were performed on 356 patients with diabetic limb infections. Three hundred and five patients had medical records available for abstraction. The median age was 55 (range: 22\u201384\u00a0years), and 160 were male (52.5%). Trauma was the most common cause of ulceration (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0135, 44.3%). Delayed presentation was common with 100 patients (32.8%) presenting more than 30\u00a0days after symptom onset. The mean Wagner score on presentation was 3.6 (STD: 0.8, range: 2\u20135). Most patients (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0293, 96%) experienced surgical delays. Among all patients who underwent major limb amputation, 38 (10.7%) died prior to discharge. The mean linear distance between patient villages and surgical centers was 53.6\u00a0km. Greater distance was associated with more delayed presentation (Correlation Coeff: 0.14,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03) and higher Wagner scores (Kruskal\u2013Wallis statistic: 10.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01). Multivariable logistic regression indicated that males were more likely to undergo above\u2010knee amputation as compared to females (OR: 2.13,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.009). Further multivariable modeling demonstrated that male sex was correlated with higher wait times from presentation to amputation (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.035).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Major limb amputation is a costly and radical procedure which contributes to severe disability in the local context. Upstream interventions to manage diabetes and facilitate access to surgical care are likely to prevent limb loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70000","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T04:14:22Z","timestamp":1752552862000},"page":"2266-2274","source":"Crossref","is-referenced-by-count":2,"title":["Diabetes\u2010Associated Major Limb Amputation in Solomon Islands: A National, 5\u2010Year Retrospective Study"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8595-7367","authenticated-orcid":false,"given":"Dylan M.","family":"Bush","sequence":"first","affiliation":[{"name":"Division of Biology and Medicine The Warren Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian Garcia","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Data Science Institute, Fu Foundation School of Engineering and Applied Science Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Pickard","sequence":"additional","affiliation":[{"name":"School of Public Health University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"World Health Organization Country Office for Solomon Islands  Honiara Solomon Islands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rooney","family":"Jagilly","sequence":"additional","affiliation":[{"name":"National Referral Hospital Solomon Islands Ministry of Health and Medical Services  Honiara Solomon Islands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micky","family":"Olangi","sequence":"additional","affiliation":[{"name":"Kilu'ufi Hospital Solomon Islands Ministry of Health and Medical Services  Auki Solomon Islands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Buin","sequence":"additional","affiliation":[{"name":"Gizo Hospital Solomon Islands Ministry of Health and Medical Services  Gizo Solomon Islands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of City and Regional Planning University of California  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrick","family":"Kaniki","sequence":"additional","affiliation":[{"name":"Helena Goldie Hospital Solomon Islands Ministry of Health and Medical Services  Munda Solomon Islands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jones","family":"Ghabu","sequence":"additional","affiliation":[{"name":"National Referral Hospital Solomon Islands Ministry of Health and Medical Services  Honiara Solomon Islands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Quity","sequence":"additional","affiliation":[{"name":"Buala Hospital Solomon Islands Ministry of Health and Medical Services  Buala Solomon Islands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra L.","family":"Martiniuk","sequence":"additional","affiliation":[{"name":"Dalla Lana School of Public Health The University of Toronto  Toronto Canada"},{"name":"The George Institute for Global Health Sydney Medical School The University of Sydney  Barangaroo Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"IDF Diabetes Atlas","author":"Boyko E. 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