{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:58:24Z","timestamp":1787237904949,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Conventional definitive treatments of relapsed Graves' disease (GD) include surgery and radioiodine therapy (RAI). Recently, radiofrequency ablation (RFA) has emerged as a potential novel treatment option. This study compared the health\u2010related quality of life (HRQOL) at 2\u00a0years after treatment of relapsed GD with RFA, surgery, and RAI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with persistent\/relapsed GD who underwent RFA, surgery (total thyroidectomy), or RAI at the same tertiary endocrine surgery unit from 2020 to 2022 were recruited to complete the disease\u2010specific (ThyPRO\u201039) and generic (SF\u201012V2, SF\u20106D and EQ\u20105D\u20105L) HRQOL questionnaires at two years after each of the above respective treatments. Composite and domain specific scores were compared after propensity score matching for baseline age, sex, thyroid function, and comorbidities. Patients with moderate to severe Graves ophthalmopathy were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010five patients completed the questionnaires. In the matched cohort, 45 patients (RFA: 15, Surgery: 15, RAI: 15) were analyzed. Their median age was 34 (30 \u2013 44), and majority were female patients (91%). For the thyroid disease\u2010specific ThyPRO\u201039 questionnaire, the RFA group had significantly lower (better) scores for depressive symptoms than the RAI and surgery groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.046 and 0.009, respectively). The RFA group also had lower (better) scores for anxiety symptoms, hypothyroid symptoms, tiredness, overall quality of life impact scale, and composite scale, albeit differences being not statistically significant. In generic questionnaires, comparable composite scores were observed. These include the physical component score and mental component score in SF\u201012v2, the SF\u20106D utility score, EQ\u20105D\u20105L utility score, and EQ\u2010VAS score. Sensitivity analysis with inverse probability of treatment weighting yielded consistent results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>At 2\u00a0years after treatment of relapsed GD, single\u2010session RFA achieved significantly better outcomes in terms of less depressive symptoms and at least comparable outcomes in most HRQOL domains when compared to surgery and RAI, when a disease\u2010specific questionnaire (ThyPRO\u201039) was used. Comparable outcomes from generic HRQOL questionnaires were noted across RFA, surgery, and RAI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70035","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T13:21:13Z","timestamp":1756387273000},"page":"3142-3151","source":"Crossref","is-referenced-by-count":3,"title":["Comparing the Health\u2010Related Quality of Life at Two Years After Successful Treatment of Relapsed Graves' Disease With Radiofrequency Ablation, Surgery, or Radioiodine"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2812-0616","authenticated-orcid":false,"given":"Man Him Matrix","family":"Fung","sequence":"first","affiliation":[{"name":"Department of Surgery School of Clinical Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Queen Mary Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2592-8310","authenticated-orcid":false,"given":"Xiaodong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Clinical Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Queen Mary Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9813-1126","authenticated-orcid":false,"given":"David Tak Wai","family":"Lui","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Clinical Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Queen Mary Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0164-5260","authenticated-orcid":false,"given":"Yan","family":"Luk","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Clinical Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Queen Mary Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6895-6071","authenticated-orcid":false,"given":"Carlos King Ho","family":"Wong","sequence":"additional","affiliation":[{"name":"Laboratory of Data Discovery for Health (D24H)  Hong Kong China"},{"name":"Department of Family Medicine and Primary Care School of Clinical Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong  Hong Kong China"},{"name":"Department of Infectious Disease Epidemiology Faculty of Epidemiology and Population Health London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9362-0086","authenticated-orcid":false,"given":"Brian Hung","family":"Hin Lang","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Clinical Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Queen Mary Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra042972"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0229"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003930"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010023\u201009620\u20101"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2024.0177"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2018.0315"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955\u2010023\u201002177\u2010z"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2011.12.5.525"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2018.19.4.632"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010018\u20101857\u20109"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0209"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168\u20108510(90)90421\u20109"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273\u2010018\u20100623\u20108"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2012.02.008"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40271\u2010017\u20100278\u20100"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2019.02.014"},{"key":"e_1_2_11_18_1","first-page":"77","article-title":"Population Norm of Chinese (HK) SF\u201012 Health Survey_Version2 of Chinese Adults in Hong Kong","volume":"32","author":"Lam C. 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