{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T20:40:23Z","timestamp":1788640823069,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002999","name":"Ministerie van Volksgezondheid, Welzijn en Sport","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002999","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treatment paradigms for patients with locally recurrent rectal cancer (LRRC) have shifted from palliative approaches to multimodal curative\u2010intent treatment in selected patients. This retrospective cohort study evaluates survival outcomes following curative\u2010intent treatment in patients with LRRC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      All consecutive patients with LRRC undergoing curative\u2010intent treatment at a tertiary referral center between 2014 and 2024 were retrospectively analyzed (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0147). Overall survival (OS), local re\u2010recurrence\u2010free survival (LRFS), metastasis\u2010free survival (MFS), and prognostic factors were analyzed using Kaplan\u2013Meier and Cox regression analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      147 patients underwent neoadjuvant treatment with curative intent at baseline. After response assessment, 117\/147 (80%) patients continued curative therapy, which consisted of 109\/117 (93%) patients undergoing surgery and a highly selected group of 8\/117 (7%) patients monitored with a watch\u2010and\u2010wait strategy. For the remaining 30\/147 patients (20%), treatment intent changed from curative to palliative. Median OS was 54\u00a0months with a 5\u2010year OS of 47%. For patients treated with an overall curative intent (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0117), median OS was 63\u00a0months with a 5\u2010year OS of 58%. Clear resection margins, achieved in 76% of surgical cases, was a prognostic factor for OS and LRFS: 5\u2010year OS was 66% for R0\u2010resections and 33% for R1\u2010resections (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and 3\u2010year RFS was 69% for R0\u2010resections and 50% for R1\u2010resections (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Among the watch\u2010and\u2010wait group, 5\/8 patients remained alive and disease\u2010free (median follow\u2010up 14\u00a0months (IQR 9\u201316)).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This single\u2010center retrospective cohort study demonstrates reasonably good oncological outcomes following curative\u2010intent LRRC treatment. Further investigation of watch\u2010and\u2010wait strategies in highly selected patients is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70135","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:29:26Z","timestamp":1759973366000},"page":"3067-3077","source":"Crossref","is-referenced-by-count":1,"title":["Oncological Outcomes of Locally Recurrent Rectal Cancer Treated With Curative Intent: A Single Center Retrospective Cohort Study"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9418-5101","authenticated-orcid":false,"given":"F. E. C. Vande","family":"Kerckhove","sequence":"first","affiliation":[{"name":"GROW Research Institute for Oncology and Reproduction Maastricht University  Maastricht the Netherlands"},{"name":"Department of Surgery Netherlands Cancer Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. G. J.","family":"Aalbers","sequence":"additional","affiliation":[{"name":"Department of Surgery Netherlands Cancer Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. C.","family":"Groen","sequence":"additional","affiliation":[{"name":"Department of Surgery Netherlands Cancer Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Snaebjornsson","sequence":"additional","affiliation":[{"name":"Department of Pathology Netherlands Cancer Institute  Amsterdam the Netherlands"},{"name":"Faculty of Medicine University of Iceland  Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"van Triest","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Netherlands Cancer Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. L.","family":"Beets","sequence":"additional","affiliation":[{"name":"GROW Research Institute for Oncology and Reproduction Maastricht University  Maastricht the Netherlands"},{"name":"Department of Surgery Netherlands Cancer Institute  Amsterdam the Netherlands"},{"name":"Department of Surgery Maastricht University Medical Centre  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brechtje A.","family":"Grotenhuis","sequence":"additional","affiliation":[{"name":"Department of Surgery Netherlands Cancer Institute  Amsterdam the 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