{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T09:35:31Z","timestamp":1771061731183,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Aim of this study is to evaluate the prognostic role of nodal parameter in early stage pathologically patients with N0 who underwent lobectomy and lymphadenectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Clinical and pathological characteristics of patients who underwent anatomical lung resection from 1\/01\/2010 to 31\/12\/2019 were reviewed and retrospectively analyzed. GGO and part\u2010solid tumors, MIA, AIS, more than 5\u00a0cm in size, with nodal and\/or distant metastases, or receiving neoadjuvant treatment were excluded. Operatory and pathological report were reviewed to collect data on lymphadenectomy. The primary end\u2010point was disease\u2010free survival (DFS), calculated from surgery to recurrence appearance. Clinical\/pathological characteristics and nodal parameters were associate to DFS using Kaplan\u2013Meier curves. The log\u2010rank test was used to assess differences between subgroups. A multivariable model was built using Cox\u2010regression analysis, including variable resulting significant (\n                      <jats:italic>p<\/jats:italic>\n                      value\u00a0&lt;\u00a00.05), at univariable analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The final analysis was conducted on 487 patients. Most patients presented stage I tumor (82.4%). The mean number of resected nodes (#RN), resected N1 (#RN1) nodes, and resected N2 nodes (#RN2) resulted 9.5\u00a0\u00b1\u00a08.0, 3.4\u00a0\u00b1\u00a04.3, and 5.9\u00a0\u00b1\u00a04.4. The mean number of total resected stations (#RS), N1 resected stations (#RSN1), and N2 resected stations (#RSN2) resulted 2.5\u00a0\u00b1\u00a01.6, 1\u00a0\u00b1\u00a00.8, and 1.5\u00a0\u00b1\u00a01.2, respectively. During a mean follow\u2010up of 43\u00a0\u00b1\u00a028\u00a0months, a recurrence occurred in 137 (28.1%) patients. At univariable analysis, age\u00a0&lt;\u00a070\u00a0years (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.025), N1 lymphadenectomy (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.019), #RSN1\u00a0\u2265\u00a03 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001), #RN\u00a0\u2265\u00a010 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.019), #RN1\u00a0\u2265\u00a03 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), node sampling with more than 3 resected nodes (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.049), at least 3 stations with 3 N1 nodes resected (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.013), at least 3 stations resected with 10 lymphnodes, and 3N1 lymphnodes (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.020) significantly correlated with improved DFS. Multivariable analysis confirmed as independent prognostic factor #RN1\u00a0\u2265\u00a03 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.017; HR 1.782; and 95% CI: 1.107\u20132.867). Patients with #RN1\u00a0\u2265\u00a03 presented a 5\u2010years DFS of 76.3% versus 57.8% of patients with #RN1\u00a0&lt;\u00a03 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hilar lymphadenectomy seems to significantly correlate with disease\u2010free survival in patients with pN0NSCLC and should be better defined in lymphadenectomy guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70144","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T04:45:32Z","timestamp":1760503532000},"page":"404-412","source":"Crossref","is-referenced-by-count":1,"title":["Hilar Lymphadenectomy Is Associated With Improved Disease\u2010Free Survival in Pathologically N0 Non\u2010Small Cell Lung Cancer"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3807-6911","authenticated-orcid":false,"given":"Marco","family":"Chiappetta","sequence":"first","affiliation":[{"name":"Thoracic Surgery Unit Magna Graecia University  Catanzaro Italy"},{"name":"Thoracic Surgery Unit Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4654-1577","authenticated-orcid":false,"given":"Carolina","family":"Sassorossi","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Thoracic Surgery Unit Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Lococo","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Thoracic Surgery Unit Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Meacci","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Thoracic Surgery Unit Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Congedo","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Thoracic Surgery Unit Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Campanella","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Fondazione Policlinico Universitario A. 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