{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:16:15Z","timestamp":1789060575471,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Secondary and tertiary hyperparathyroidism (SHPT and THPT) are frequent complications of chronic kidney disease and kidney transplantation, often impairing quality of life (QoL) through bone pain, fatigue, and pruritus. Parathyroidectomy is the definitive treatment for refractory cases, yet its impact on patient\u2010reported QoL outcomes remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a systematic review and meta\u2010analysis in accordance with PRISMA guidelines (PROSPERO CRD42025108038). Nine studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0675) with validated QoL assessments and \u2265\u00a06\u00a0months of follow\u2010up were included. QoL was measured using SF\u201036, KDQOL, and Pasieka\u2019s parathyroid assessment of symptoms (PAS). Standardized mean differences (SMDs) were calculated, with analyses of physical (PCS) and mental (MCS) component summary scores. Meta\u2010regression evaluated preoperative parathyroid hormone (PTH), calcium, and phosphorus as predictors of QoL change.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Parathyroidectomy significantly improved global QoL (Hedges'\n                      <jats:italic>g<\/jats:italic>\n                      \u00a0=\u00a01.05; 95% CI: 0.42\u20131.69;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0011), PCS (SMD\u00a0=\u00a00.85; 95% CI: 0.32\u20131.37;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and MCS (SMD\u00a0=\u00a00.40; 95% CI: 0.11\u20130.69;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001). PAS scores also improved (SMD\u00a0=\u00a0\u22121.66; 95% CI: \u22122.72 to \u22120.60;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004). Preoperative PTH, calcium, and phosphorus were not associated with postoperative QoL gains (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.71, 0.54, 0.47). Both subtotal and total parathyroidectomy provided comparable benefits (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.76).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Parathyroidectomy leads to meaningful QoL improvements in CKD\u2010related hyperparathyroidism, regardless of surgical technique. Baseline biochemical markers do not predict postoperative gains. Standardized, long\u2010term studies of patient\u2010reported outcomes are needed to guide surgical decision\u2010making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70211","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T03:21:10Z","timestamp":1766200870000},"page":"94-104","source":"Crossref","is-referenced-by-count":1,"title":["Quality of Life After Parathyroidectomy in Chronic Kidney Disease\u2013Related Hyperparathyroidism: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7315-6079","authenticated-orcid":false,"given":"Wellington","family":"Alves Filho","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery Hospital Universit\u00e1rio Walter Cantidio (HUWC\/EBSERH) Faculty of Medicine of the Federal University of Ceara (UFC)  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia","family":"D'Elboux Guimar\u00e3es Brescia","sequence":"additional","affiliation":[{"name":"Parathyroid Unit\u2014LIM\u201028, Head and Neck Surgery Laboratory, Division of Head and Neck Surgery, Department of Surgery Hospital das Clinicas (HCFMUSP) University of S\u00e3o Paulo School of Medicine (FMUSP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Ferraz","family":"Magnabosco","sequence":"additional","affiliation":[{"name":"Parathyroid Unit\u2014LIM\u201028, Head and Neck Surgery Laboratory, Division of Head and Neck Surgery, Department of Surgery Hospital das Clinicas (HCFMUSP) University of S\u00e3o Paulo School of Medicine (FMUSP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murilo","family":"Catafesta das Neves","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery Federal University of Sao Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Samir","family":"Arap","sequence":"additional","affiliation":[{"name":"Hospital Sirio Liban\u00eas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Oliveira","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery Federal University of Sao Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana\u00edna","family":"de Almeida Mota Ramalho","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Faculty of Medicine of the Federal University of Ceara (UFC)  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5749-2363","authenticated-orcid":false,"given":"Fabio","family":"Luiz de Menezes Montenegro","sequence":"additional","affiliation":[{"name":"Parathyroid Unit\u2014LIM\u201028, Head and Neck Surgery Laboratory, Division of Head and Neck Surgery, Department of Surgery Hospital das Clinicas (HCFMUSP) University of S\u00e3o Paulo School of Medicine (FMUSP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio Ribeiro","family":"Studart da Fonseca","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Hospital Universit\u00e1rio Walter Cantidio (HUWC\/EBSERH) Faculty of Medicine of the Federal University of Ceara (UFC)  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2215\/cjn.10390917"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109610(05)80537\u20109"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2020.06.043"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1098\u20102388(199703\/04)13:2<87::aid\u2010ssu4>3.0.co;2\u2010y"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423\u2010015\u20101344\u20105"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2018.06.032"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2013.08.013"},{"issue":"6","key":"e_1_2_11_9_1","first-page":"511","article-title":"Measurement of Quality of Life After Total Parathyroidectomy in Patients With Secondary Hyperparathyroidism and End Stage Renal Disease","volume":"110","author":"Bratucu M. 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