{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:59:58Z","timestamp":1784807998750,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>PANP has been applied in laparoscopic radical rectal cancer resection, significantly reducing the incidence of genitourinary dysfunction; however, it has not eliminated sexual and urinary dysfunction. Prospective trials focusing on genitourinary function as a primary outcome are rare. To confirm the protective effect on sexual and urinary function in laparoscopic radical resection of rectal cancer with pelvic autonomic nerve preservation (PANP), and explore the risk factor of postoperative sexual dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, single\u2010center, single\u2010arm trial was conducted on male patients with rectal adenocarcinoma suitable for laparoscopic surgery with PANP at Sun Yat\u2010sen Memorial Hospital, Sun Yat\u2010sen University. Patients with normal genitourinary function were included, and the primary outcome was the change in sexual function 6\u00a0months after the operation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 91 patients enrolled, 70 underwent a laparoscopic operation. Six months after the operation, 5 patients were lost to follow\u2010up, and the IIEF\u20105 and IPSS scores were 22.85\u00a0\u00b1\u00a03.66 versus 24.10\u00a0\u00b1\u00a01.21 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003) and 2.11\u00a0\u00b1\u00a02.06 versus 1.89\u00a0\u00b1\u00a01.86 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.018), respectively, compared with preoperative values. Five patients (7.69%) suffered from sexual disorders, and 2 patients (3.08%) developed moderate urinary dysfunction. The majority of the autonomic nerve system was visible and preserved intraoperatively. Quality of TME was complete in 94.29% (66\/70) and partially complete in 5.71% (4\/70) of patients, respectively. Positive CRM in this study was 2.86% (2\/70), and positive distal resection margin was 1.43% (1\/70). The mean postoperative hospital stay was 7.80\u00a0\u00b1\u00a02.44\u00a0days. Surgical procedure, distance of tumor to AV, clinical TNM stage, nCRT, stoma, and completeness of the autonomic nervous system were risk factors of postoperative sexual dysfunction in univariate analysis; however, none of them was an independent risk factor in multivariate analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PANP in laparoscopic radical rectal resection effectively preserves sexual and urinary function without compromising oncological outcomes. It is safe and feasible in high\u2010flow centers and for experienced surgeons.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70224","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:08:20Z","timestamp":1769832500000},"page":"569-579","source":"Crossref","is-referenced-by-count":1,"title":["Laparoscopic Rectal Cancer Resection With Pelvic Autonomic Nerve Preservation in Males: A Prospective Single\u2010Center Study"],"prefix":"10.1002","volume":"50","author":[{"given":"Yequan","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery Guangdong Second Provincial General Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyu","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Guangdong Second Provincial General Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5587-4827","authenticated-orcid":false,"given":"Fanghai","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Guangdong Second Provincial General Hospital  Guangzhou China"},{"name":"Department of Gastrointestinal Surgery Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengning","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Guangdong Second Provincial General Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Guangdong Second Provincial General Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2022.02.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800691019"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.133.8.894"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa010580"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa040694"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000171299.43954.ce"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/gow023"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350\u2010004\u20106388\u20105"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102168.2000.01357.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.2000.0998"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350\u2010004\u20100618\u20108"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.23922\/jarc.2019\u2010018"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010009\u20100566\u20104"},{"issue":"7","key":"e_1_2_10_16_1","first-page":"3148","article-title":"Three\u2010Dimensional Versus Two\u2010Dimensional Laparoscopic Surgery for Rectal Cancer: Better Promote Postoperative Sexual and Urinary Function of a Propensity\u2010Matched Study","volume":"12","author":"Han F. 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