{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:41:07Z","timestamp":1780393267297,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Biologic mesh has historically been used for ventral hernia repairs (VHR) in contaminated fields in an off\u2010label fashion due to early evidence suggesting that they may be able to withstand these conditions more favorably than synthetic mesh. This study aims to compare outcomes of two non\u2010crosslinked porcine acellular dermal matrices\u2014XenMatrix (Bard, Covington, GA) and Strattice (LifeCell Corporation, Bridgewater, NJ) used in VHR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who were undergoing elective open VHR were randomized to receive either XenMatrix or Strattice mesh (randomized controlled trial\u2014RCT cohort). An additional cohort of patients were recruited in a retrospective observational study cohort. Surgical site occurrence (SSO) was the primary outcome evaluated with hernia recurrence being a secondary outcome measure. Simple and multivariate logistic regression analyses were conducted separately for the RCT and observational cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010six patients were randomized into the RCT cohort, and an additional 20 patients were recruited into the observational study cohort. There was no difference in baseline characteristics between the two mesh groups in both the RCT and observational cohorts. In the RCT cohort, the 6\u2010week SSO rate was significantly higher for XenMatrix (36.7%) than Strattice (6.3%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03), and on multivariate analysis, XenMatrix was associated with higher 6\u2010week SSO risk than Strattice [OR: 19.5 (95% CI: 2.3\u2013523.7) and\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02]. However, in the observational cohort, the rate of 6\u2010week SSO was similar for both XenMatrix (50.0%) and Strattice (33.3%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.46) as well in the multivariate analysis [OR: 6.6 (95% CI: 0.4\u2013324.6) and\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.23]. Finally, random effect meta\u2010analysis of 6\u2010week risk of SSO of both RCT and observational cohort showed that XenMatrix is associated with higher 6\u2010week SSO risk than Strattice [OR: 12.5 (95% CI: 1.8\u201389.2) and\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00%\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.012].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study showed that XenMatrix may be associated with higher risk of early SSO compared to Strattice. This underscores the importance of more head\u2010to\u2010head mesh comparison to optimize outcomes following VHR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      NCT02228889 (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">www.clinicaltrials.gov<\/jats:ext-link>\n                      )\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70271","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T02:25:03Z","timestamp":1771640703000},"page":"848-859","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Outcomes of Two Non\u2010Crosslinked Porcine Acellular Dermal Matrices in Complex Abdominal Wall Reconstruction: A Randomized Controlled Trial and an Observational Cohort Study"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8891-6162","authenticated-orcid":false,"given":"Abdulaziz","family":"Elemosho","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, College of Medicine The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Sarac","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, College of Medicine The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly A.","family":"Olson","sequence":"additional","affiliation":[{"name":"Independent Researcher"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Khansa","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Texas Children's Hospital\u2010North Austin  Austin Texas USA"},{"name":"Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige N.","family":"Hackenberger","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vimal","family":"Narula","sequence":"additional","affiliation":[{"name":"Department of Surgery The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Eiferman","sequence":"additional","affiliation":[{"name":"Department of Surgery The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Janis","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, College of Medicine The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000141193.08524.e7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.01.008"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2020.01.001"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000002549"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010200301000\u201000018"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2024.0233"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000006294"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011517.pub2"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1051\/bmdcn\/2017070316"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.5505\/tjtes.2018.59263"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100034\u20101394155"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2008.12.033"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481107700210"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100039\u20101693019"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/XCS.0000000000001412"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2018.10.009"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviscsurg.2021.06.001"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010013\u20102232\u20101"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2023.07.003"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2022.12.002"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2022.342"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000004835"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182729e58"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2012.08.012"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000010292"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.6902"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102016\u2010313541"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000018"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2025.03.002"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjebm\u20102020\u2010111493"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100258(20001230)19:24<3359::aid\u2010sim710>3.0.co;2\u2010n"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.04.008"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e31822f997b"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10029\u2010019\u201002068\u20107"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010023\u201007154\u20107"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004454"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000000695"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000004083"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2011.04.035"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12558"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2023.11.013"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182849871"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.07.083"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.09.070"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/2041731413505305"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/app10103435"}],"container-title":["World 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