{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T17:45:52Z","timestamp":1776015952692,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bilobar colorectal liver metastases (CRLMs) are often addressed through a two\u2010stage hepatectomy (TSH) strategy. The outcomes of TSH according to the presence of criteria used for Liver Transplantation (LT) for unresectable CRLMs has yet to be investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective review of 100 consecutive patients treated with a TSH. Patients were categorized based on the presence of ideal LT criteria, and compared. The selection criteria included: (1) absence of extrahepatic disease, (2) no metastatic lymph nodes in the hepatic pedicle, (3) tumor diameter less than 55\u00a0mm, (4) no disease progression before or between the two surgical stages, and (5) preoperative serum carcinoembryonic antigen (CEA) levels below 80\u00a0\u03bcg\/L.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Based on the selection criteria, 30 patients filled LT criteria, while 70 patients fell outside these criteria. The median overall survival and the survival rates at 1, 3, and 5\u00a0years were significantly higher for patients within the LT criteria, with median overall survival of 57\u00a0months, and survival rates of 93%, 71%, and 49%, respectively, compared to 27.2\u00a0months, 79%, 41%, and 19% for those outside the criteria (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Characteristics of patients in the two groups were largely similar, except that the transplant\u2010criteria group was younger and had a lower Fong's score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients undergoing TSH for bilobar CRLMs, ideally selected based on strict LT criteria, experienced very favorable long\u2010term survival outcomes. The potential role of LT for bilobar CRLMs addressed through a TSH strategy warrant further investigation in a randomized study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70278","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T03:39:24Z","timestamp":1771558764000},"page":"975-984","source":"Crossref","is-referenced-by-count":0,"title":["Two\u2010Stage Hepatectomy for Bilobar Colorectal Liver Metastases: Outcomes According to Liver Transplant Selection Criteria"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-7973","authenticated-orcid":false,"given":"Pietro","family":"Addeo","sequence":"first","affiliation":[{"name":"Hepato\u2010Pancreato\u2010Biliary Surgery and Liver Transplantation P\u00f4le des Pathologies Digestives et H\u00e9patiques H\u00f4pital de Hautepierre\u2010H\u00f4pitaux Universitaires de Strasbourg Universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Canali","sequence":"additional","affiliation":[{"name":"Hepato\u2010Pancreato\u2010Biliary Surgery and Liver Transplantation P\u00f4le des Pathologies Digestives et H\u00e9patiques H\u00f4pital de Hautepierre\u2010H\u00f4pitaux Universitaires de Strasbourg Universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Narita","sequence":"additional","affiliation":[{"name":"Hepato\u2010Pancreato\u2010Biliary Surgery and Liver Transplantation P\u00f4le des Pathologies Digestives et H\u00e9patiques H\u00f4pital de Hautepierre\u2010H\u00f4pitaux Universitaires de Strasbourg Universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Marchitelli","sequence":"additional","affiliation":[{"name":"Hepato\u2010Pancreato\u2010Biliary Surgery and Liver Transplantation P\u00f4le des Pathologies Digestives et H\u00e9patiques H\u00f4pital de Hautepierre\u2010H\u00f4pitaux Universitaires de Strasbourg Universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chloe","family":"Paul","sequence":"additional","affiliation":[{"name":"Hepato\u2010Pancreato\u2010Biliary Surgery and Liver Transplantation P\u00f4le des Pathologies Digestives et H\u00e9patiques H\u00f4pital de Hautepierre\u2010H\u00f4pitaux Universitaires de Strasbourg Universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"De Mathelin","sequence":"additional","affiliation":[{"name":"Hepato\u2010Pancreato\u2010Biliary Surgery and Liver Transplantation P\u00f4le des Pathologies Digestives et H\u00e9patiques H\u00f4pital de Hautepierre\u2010H\u00f4pitaux Universitaires de Strasbourg Universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Faitot","sequence":"additional","affiliation":[{"name":"Hepato\u2010Pancreato\u2010Biliary Surgery and Liver Transplantation P\u00f4le des Pathologies Digestives et H\u00e9patiques H\u00f4pital de Hautepierre\u2010H\u00f4pitaux Universitaires de Strasbourg Universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Bachellier","sequence":"additional","affiliation":[{"name":"Hepato\u2010Pancreato\u2010Biliary Surgery and Liver Transplantation P\u00f4le des Pathologies Digestives et H\u00e9patiques H\u00f4pital de Hautepierre\u2010H\u00f4pitaux Universitaires de Strasbourg Universit\u00e9 de Strasbourg  Strasbourg 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