{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T05:05:25Z","timestamp":1779426325898,"version":"3.53.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Importance<\/jats:title>\n Reoperative parathyroidectomy is necessary in up to 10% of patients with persistent or recurrent primary hyperparathyroidism. Accurate preoperative localization is critical for surgical success and minimizing complications. Conventional imaging methods often yield inconclusive or false\u2010negative results in this challenging patient population.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To evaluate the diagnostic accuracy and clinical utility of 18F\u2010fluorocholine positron emission tomography\/computed tomography imaging compared to traditional imaging modalities of neck ultrasonography and\n 99m<\/jats:sup>\n Technetium\u2014sestamibi parathyroid scintigraphy in patients undergoing reoperative parathyroidectomy.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Retrospective cohort study of patients undergoing reoperative parathyroidectomy over a 20\u2010year period (2005\u20132025). Localization imaging modalities, operative approaches, intraoperative parathyroid hormone monitoring, and surgical outcomes were analyzed.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Single tertiary referral center specializing in endocrine surgery with a high\u2010volume parathyroidectomy practice.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n 114 consecutive adult patients (aged \u2265\u00a018\u00a0years) were included who underwent 124 reoperative parathyroidectomy operations for biochemically confirmed persistent or recurrent primary hyperparathyroidism. Patients were included if there was lithium\u2010associated hyperparathyroidism or multiple endocrine neoplasia type 1 syndrome.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n Primary outcome included localization detection rates of imaging modalities performed. Secondary outcomes included type of surgical approach utilized, cause of failure from the primary operation, intraoperative parathyroid hormone monitoring response, biochemical cure rate, and surgical complications.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n 18F\u2010fluorocholine positron emission tomography\/computed tomography demonstrated a detection rate of 95.2%, outperforming 11C\u2010methionine positron emission tomography\/computed tomography (63.6%), fludeoxyglucose\u2014positron emission tomography\/computed tomography (50.0%), and neck ultrasonography (21.6%). In 90.5% of cases with negative or inconclusive conventional imaging, 18F\u2010fluorocholine positron emission tomography\/computed tomography accurately localized pathological parathyroid gland(s). A focused surgical approach (sternotomy or unilateral cervicotomy) was feasible in 87.1% of patients. Appropriate intraoperative parathyroid hormone monitoring decline was associated with a 95.8% biochemical cure rate. Complication rates were low, with vocal cord palsy in 0.8% and long\u2010term hypoparathyroidism requiring calcium supplementation in 2.4%.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n 18F\u2010fluorocholine positron emission tomography\/computed tomography offers superior localization accuracy and a favorable radiation profile compared to conventional imaging options, supporting its use as a first\u2010line modality in reoperative parathyroidectomy. Its application enables focused surgical interventions with high cure rates and low morbidity.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/wjs.70332","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:47:21Z","timestamp":1774331241000},"page":"1312-1318","source":"Crossref","is-referenced-by-count":0,"title":["18F\u2010Choline PET\/CT Localization in a 20\u2010Year Experience of Re\u2010Operative Parathyroidectomy"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9141-8386","authenticated-orcid":false,"given":"Anh N.","family":"Vu","sequence":"first","affiliation":[{"name":"Department of Endocrine Surgery Guy's and St Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4245-0328","authenticated-orcid":false,"given":"Katherine A.","family":"Black","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Guy's and St Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0126-621X","authenticated-orcid":false,"given":"Osama","family":"Shattarah","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Guy's and St Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Preece","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Guy's and St Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2253-6626","authenticated-orcid":false,"given":"Johnathan G.","family":"Hubbard","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Guy's and St Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326\u20105377.1998.tb126768.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.134.7.699"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf01655524"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2008.07.022"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1500019"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010018\u20104123\u2010z"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149\u2010020\u201001507\u20101"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11122384"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010019\u201004910\u20106"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2019.0059"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010020\u201002487\u2010y"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010018\u20104018\u2010z"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2020.11.027"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.109561"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.23736\/s0391\u20101977.17.02685\u20102"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25023"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2007.08.004"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010010\u20100569\u20102"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.07.1731"},{"issue":"6","key":"e_1_2_12_21_1","first-page":"1028","article-title":"Primary Hyperparathyroidism During Pregnancy","volume":"110","author":"Kelly T. R.","year":"1991","journal-title":"Surgery"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254\u2010200206000\u201000022"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010017\u20104395\u20107"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjs.70332","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/wjs.70332","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjs.70332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T04:08:24Z","timestamp":1779422904000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/wjs.70332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/wjs.70332"],"URL":"https:\/\/doi.org\/10.1002\/wjs.70332","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]}}}