{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T05:04:57Z","timestamp":1779426297583,"version":"3.53.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study compares the outcomes in patients undergoing ventral hernia repair using intraperitoneal underlay mesh (IPUM) without facial defect closure versus intraperitoneal underlay mesh following fascial defect closure (IPUM+).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To search for randomized controlled trials comparing outcomes of patients with ventral hernias who were managed surgically with either IPUM or IPUM+, standard medical databases such as MEDLINE, Embase, PubMed, and Cochrane Library were used, covering studies published up to and including September 2025. The meta\u2010analysis was performed with a random effect model analysis, and all data was analyzed using Review Manager Software 5.4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five randomized controlled trials (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0549) were included, involving adult patients who underwent laparoscopic ventral hernia repair with IPUM or IPUM+. The pooled analysis showed no significant difference in hernia recurrence (Risk Ratio [RR]: 0.82, 95% CI: [0.29, 2.27],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.70), seroma formation (RR: 0.78, 95% CI: [0.32, 1.88],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.58), operating times (Standard Mean Difference [SMD]: 0.26, 95% CI [\u22120.17, 0.69],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.23) and pain scores (SMD: 0.26, 95% CI [\u22120.17, 0.69],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.23) between the two approaches.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IPUM and IPUM+ are both associated with similar postoperative morbidities for the treatment of ventral hernia repair.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70338","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T04:50:07Z","timestamp":1774932607000},"page":"1252-1261","source":"Crossref","is-referenced-by-count":0,"title":["A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials on Fascial Defect Closure Versus Bridged Repair in Laparoscopic Ventral Hernia Mesh Repair"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5852-7035","authenticated-orcid":false,"given":"Moadh","family":"Hwessa","sequence":"first","affiliation":[{"name":"Brighton and Sussex Medical School  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5731-1585","authenticated-orcid":false,"given":"Wajeeh Ullah","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Brighton and Sussex Medical School  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Lubbad","sequence":"additional","affiliation":[{"name":"Brighton and Sussex Medical School  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Royal Sussex County Hospital  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goldie","family":"Khera","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Royal Sussex County Hospital  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad S.","family":"Sajid","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Royal Sussex County Hospital  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40137\u2010024\u201000435\u20107"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpsur.2023.11.007"},{"key":"e_1_2_11_4_1","unstructured":"C.Macutkiewicz Abdominal Hernia | Health Information | Bupa UK (2024) [Internet][cited 2025 Oct 1] https:\/\/www.bupa.co.uk\/health\u2010information\/digestive\u2010gut\u2010health\/abdominal\u2010hernia."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10029\u2010019\u201002098\u20101"},{"issue":"2","key":"e_1_2_11_6_1","first-page":"117","article-title":"Laparoscopic Ventral Hernia Repair: Pros and Cons Compared With Open Hernia Repair","volume":"12","author":"Misiakos E. 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