{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T05:04:52Z","timestamp":1779426292576,"version":"3.53.1"},"reference-count":7,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To synthesize evidence on the demographic and prognostic profile of surgically treated intrathyroidal thymic carcinoma (ITC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A PRISMA\u2010compliant systematic review and meta\u2010analysis was conducted. Due to the rarity of the disease, all patients with surgically treated ITC were combined from individual case reports to create a cohort of patients which was subsequently pooled with other eligible case series. Single\u2010arm meta\u2010analysis was used to synthesize a demographic profile and Kaplan\u2013Meier statistics were used for survival analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Analysis of 55 articles (154 patients) showed that patients with ITC are likely to be symptomatic (95.2%, 95% CI 91.1\u201399.2) with neck mass (72.2%, 62.2\u201382.1) as the most common symptom with no laterality preferences (left:right, 46.4%:53.6%). Overall survival (OS) at 15\u00a0years was 96.0% (mean OS time:19.7\u00a0years; median OS time 18\u00a0years). Recurrence\u2010free survival (RFS) at 15\u00a0years was 77.9% (mean RFS time:13.4\u00a0years; median RFS time: 17\u00a0years). RFS was not affected by symptomatic status (HR: 0.0001,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.96), tumor size (HR; 1.044,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.113), lymph node metastasis (HR: 1.909,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.307), extrathyroidal extension (HR: 0.769, tumor\u00a0\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.688), surgery plus radiotherapy (HR: 0.434,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.207), surgery plus chemoradiotherapy (HR: 0.0001,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.959), subtotal thyroidectomy (HR: 0.821,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.854), lobectomy (HR: 0.366,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.140), lymph node dissection (HR: 1.088,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.888).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Surgically treated ITC may have excellent long\u2010term prognosis which seems to be not affected by the extent of resection or use of adjuvant therapy; however, this could be type 2 error; hence more robust evidence is required for definitive conclusions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70345","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T17:39:18Z","timestamp":1775237958000},"page":"1328-1335","source":"Crossref","is-referenced-by-count":0,"title":["Demographic and Prognostic Significance of Surgically\u2010Treated Intrathyroidal Thymic Carcinoma: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5621-4233","authenticated-orcid":false,"given":"Cameron R.","family":"Jenkins","sequence":"first","affiliation":[{"name":"Department of General Surgery Peterborough City Hospital  Peterborough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahab","family":"Hajibandeh","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery Manchester Royal Infirmary Hospital  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6159-1068","authenticated-orcid":false,"given":"Shahin","family":"Hajibandeh","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery Queen Elizabeth Hospital  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Scott\u2010Coombes","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery University Hospital of Wales  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Egan","sequence":"additional","affiliation":[{"name":"Department of General Surgery Morriston Hospital  Swansea UK"},{"name":"School of Medicine Swansea University  Swansea UK"},{"name":"North Wales Medical School Bangor University  Bangor UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1394020"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf01656263"},{"key":"e_1_2_11_4_1","first-page":"65","volume-title":"WHO Classification of Tumours of Endocrine Organs","author":"Lloyd R. V.","year":"2017"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2023.152221"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11914"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.ej22\u20100141"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/erc\u201021\u20100123"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjs.70345","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/wjs.70345","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjs.70345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T04:06:17Z","timestamp":1779422777000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/wjs.70345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,3]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/wjs.70345"],"URL":"https:\/\/doi.org\/10.1002\/wjs.70345","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,3]]}}}