{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T17:37:04Z","timestamp":1779903424468,"version":"3.53.1"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>NCRT is a standard preoperative treatment for locally advanced RC with variable efficacy. This prospective cohort study explored HIF\u20101\u03b1 and PD\u2010L1 expression in RC and their impact on NCRT efficacy to provide a theoretical basis for effective predictive indicators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with locally advanced rectal cancer (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0128) (cT3\/T4\u2010N0 or cTany\u2010N1\/N2) were prospectively enrolled. General clinical data were collected. Preoperative tumor and adjacent non\u2010tumor tissues were obtained via pre\u2010treatment biopsy, and HIF\u20101\u03b1\/PD\u2010L1 expression was detected by qRT\u2010PCR. All patients underwent radical surgery after NCRT, with efficacy evaluated by pTRG. ROC analysis assessed the predictive value of HIF\u20101\u03b1\/PD\u2010L1 for NCRT response. Logistic regression analyzed HIF\u20101\u03b1\/PD\u2010L1 independent association with NCRT efficacy. The 5\u2010year follow\u2010up recorded survival\/recurrence; Kaplan\u2010Meier analyzed DFS\/OS, and COX regression explored the independent correlation between HIF\u20101\u03b1\/PD\u2010L1 mRNA levels and post\u2010NCRT DFS\/OS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HIF\u20101\u03b1 and PD\u2010L1 were highly expressed in tumor tissues, with higher levels in NCRT\u2010insensitive patients. Combined HIF\u20101\u03b1 and PD\u2010L1 showed better AUC for predicting NCRT insensitivity than either alone (AUC\u00a0=\u00a00.706, sensitivity\u00a0=\u00a063.24%, specificity\u00a0=\u00a073.33%). For each 1\u2010unit increase in HIF\u20101\u03b1 and PD\u2010L1, the risk of recurrence in patients increased by 1.567\u2010fold (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001, HR\u00a0=\u00a01.567, 95% CI\u00a0=\u00a01.216\u20132.018), and the risk of death increased by 1.725\u2010fold (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.000, HR\u00a0=\u00a01.725, 95% CI\u00a0=\u00a01.354\u20132.200).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HIF\u20101\u03b1 and PD\u2010L1 expression can serve as reliable indicators for predicting NCRT efficacy and poor prognosis in RC patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70352","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T14:15:27Z","timestamp":1775139327000},"page":"1169-1178","source":"Crossref","is-referenced-by-count":1,"title":["HIF\u20101\u03b1 and PD\u2010L1 as Predictive Efficacy Marker for Neoadjuvant Chemoradiotherapy in Rectal Cancer"],"prefix":"10.1002","volume":"50","author":[{"given":"Lin","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Oncology Shangdong Provincial Key Medical and Health Discipline Qingdao Central Hospital University of Health and Rehabilitation Sciences  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology Shangdong Provincial Key Medical and Health Discipline Qingdao Central Hospital University of Health and Rehabilitation Sciences  Qingdao Shandong 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