{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T09:02:47Z","timestamp":1780736567507,"version":"3.54.1"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute cholecystitis is a common surgical emergency. In high\u2010risk patients, percutaneous cholecystostomy (PC) is often used as a temporizing measure before interval cholecystectomy (IC). The optimal timing of IC remains uncertain. This study evaluates outcomes of early versus late IC following PC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Embase, The Cochrane Library, and Scopus were systematically searched from inception to November 2025 for studies comparing early and late IC after PC. Primary outcomes were perioperative complications. Secondary outcomes included intraoperative duration, blood loss, postoperative length of stay (LOS), and catheter\u2010related complications. Subgroup analyses were performed using 1\u2010month and 8\u2010week interval cut\u2010offs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve retrospective studies comprising 10,328 patients (early\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a08690; late\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01638) were included. Baseline characteristics were comparable, although BMI was slightly lower in the early IC group (MD \u22120.26, 95% CI: \u22120.50, \u22120.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03). Overall postoperative complications, major perioperative complications, bile duct injury, subtotal cholecystectomy, and mortality were similar between groups. Conversion to open surgery, operative duration, and postoperative LOS were also comparable. Intraoperative blood loss was greater in the early IC group (MD 16.65, 95% CI: 2.24, 31.06,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02). Early IC was associated with fewer catheter\u2010related complications (RR 0.38, 95% CI: 0.22, 0.66,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005). Risk ratio analysis suggested increased intra\u2010abdominal abscess in the early IC group; however, risk difference analysis showed only a small absolute increase, indicating limited clinical significance. In subgroup analysis using a 1\u2010month cut\u2010off, early IC was associated with significantly fewer postoperative complications (RR 0.67, 95% CI: 0.56, 0.79,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.00001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early IC may confer clinical benefit in appropriately selected patients, with fewer postoperative and catheter\u2010related complications despite risk of greater intraoperative blood loss. A 1\u2010month threshold may represent a pragmatic definition of late IC. A risk\u2010stratified approach remains essential, and further prospective studies are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70375","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:10:09Z","timestamp":1776784209000},"page":"1528-1544","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of Early Compared to Late Interval Cholecystectomy Post\u2010Percutaneous Cholecystostomy in Patients Diagnosed With Acute Cholecystitis: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0587-145X","authenticated-orcid":false,"given":"Feng Yi","family":"Cheo","sequence":"first","affiliation":[{"name":"Department of General Surgery Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5854-2935","authenticated-orcid":false,"given":"Eliza 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