{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T07:07:25Z","timestamp":1783840045361,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n End\u2010stage renal disease (ESRD) patients have increased gallstone disease prevalence and unique perioperative challenges. In ESRD patients awaiting renal transplantation, asymptomatic gallstones identified during pre\u2010transplant evaluation carry additional clinical significance given the disproportionate risk of post\u2010transplant biliary emergencies. Limited literature exists regarding laparoscopic cholecystectomy (LC) outcomes in this population.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n True prospective observational study, CTRI\u2010registered (CTRI\/2016\/12\/007489) was conducted from December 2016 to March 2020 at a tertiary hospital in Eastern India. ESRD patients (\n n<\/jats:italic>\n \u00a0=\u00a0109) on maintenance hemodialysis were matched 1:2 with controls (\n n<\/jats:italic>\n \u00a0=\u00a0224) based on age, sex, BMI, and gallstone characteristics. Primary outcomes included ICU admission rate, major complications (Clavien\u2010Dindo\u00a0\u2265\u00a03), and conversion to open surgery.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n ESRD patients demonstrated significantly higher complication rates (61.5% vs. 15.2%,\n p<\/jats:italic>\n \u00a0<\u00a00.001), ICU admission requirements (81.7% vs. 8.0%,\n p<\/jats:italic>\n \u00a0<\u00a00.001), and conversion rates (7.3% vs. 1.8%,\n p<\/jats:italic>\n \u00a0=\u00a00.009). Major complications occurred in 18.3% versus 0.9% (\n p<\/jats:italic>\n \u00a0<\u00a00.001). Cardiovascular complications affected 22.0% of ESRD patients versus 1.3% of controls (\n p<\/jats:italic>\n \u00a0<\u00a00.001). Mean operative time was longer (89.3\u00a0\u00b1\u00a028.4 vs. 76.2\u00a0\u00b1\u00a024.1\u00a0min,\n p<\/jats:italic>\n \u00a0<\u00a00.001). Hospital stay was extended (4.2\u00a0\u00b1\u00a02.8 vs. 2.3\u00a0\u00b1\u00a01.1\u00a0days,\n p<\/jats:italic>\n \u00a0<\u00a00.001). Independent risk factors for major complications included hemoglobin\u00a0<\u00a08\u00a0g\/dL (OR 3.24), LVEF\u00a0<\u00a050% (OR 2.89), and ASA Grade IV (OR 4.17). Subgroup analysis showed no significant difference in comorbidity burden between asymptomatic (\n n<\/jats:italic>\n \u00a0=\u00a057) and symptomatic (\n n<\/jats:italic>\n \u00a0=\u00a052) ESRD patients (all\n p<\/jats:italic>\n \u00a0>\u00a00.05). Thirty\u2010day mortality was 0.9% versus 0%.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n For ESRD patients awaiting transplantation, elective pre\u2010transplant LC is remains feasible with appropriate patient selection, preoperative optimization, and intensive postoperative monitoring, and is justified given the severe consequences of post\u2010transplant biliary emergencies, with LC\u2010related post\u2010transplant complications occurring in only 12.2% of transplanted patients, all Clavien\u2010Dindo Grade I.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n Clinical Trials Registry of India (CTRI\/2016\/12\/007489)<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/wjs.70384","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T01:55:14Z","timestamp":1779760514000},"page":"1846-1854","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative Outcomes and Complications of Laparoscopic Cholecystectomy in End\u2010Stage Renal Disease Patients: A Prospective Comparative Study"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7538-7778","authenticated-orcid":false,"given":"Shresth","family":"Manglik","sequence":"first","affiliation":[{"name":"Department of Laparoscopic, Laser and General Surgery Sir Ganga Ram Hospital Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Aftab Alam","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Urology Rabindranath Tagore International Institute of Cardiac Sciences Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0655-4705","authenticated-orcid":false,"given":"Niraj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of General and Minimal Invasive Surgery Rabindranath Tagore International Institute of Cardiac Sciences Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8442-4545","authenticated-orcid":false,"given":"Sanjay Kumar","family":"Dubey","sequence":"additional","affiliation":[{"name":"Department of General and Minimal Invasive Surgery Rabindranath Tagore International Institute of Cardiac Sciences Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6775-7321","authenticated-orcid":false,"given":"Deepak Shankar","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplant Programme Rabindranath Tagore International Institute of Cardiac Sciences Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3843-1338","authenticated-orcid":false,"given":"Pradeep","family":"Narayan","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Rabindranath Tagore International Institute of Cardiac Sciences Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"2022 USRDS Annual Data Report: Epidemiology of Kidney Disease in the United States","author":"United States Renal Data System","year":"2022"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010021\u201002279\u20100"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2022.22350"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/js9.0000000000001394"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13017\u2010019\u20100224\u20107"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520933797"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccw.2014.05.002"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.4236\/ijcm.2014.520165"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010014\u20103454\u20105"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/jmas.jmas_145_17"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022x.2011.589940"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/2141\u20109248.123508"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1807\u201059322010000400007"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i29.10399"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1002498"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084943"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2016.02.079"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613\u2010019\u20100488\u20109"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2019.03.007"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjs.70384","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/wjs.70384","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjs.70384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:09:50Z","timestamp":1783836590000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/wjs.70384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/wjs.70384"],"URL":"https:\/\/doi.org\/10.1002\/wjs.70384","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,25]]}}}