{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T07:07:21Z","timestamp":1783840041834,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radial scars (RS) and complex sclerosing lesions (CSL) are benign breast lesions often detected incidentally on imaging. Although historically managed with surgical excision, emerging evidence suggests that conservative management may be appropriate in selected patients. This study evaluated rates of upgrade and progression of RS and CSL and examined factors associated with surgical management and these outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted at two academic centers affiliated with McGill University. Adult patients diagnosed with RS or CSL on image\u2010guided core needle biopsy between 2010 and 2024 were included. Upgrade or progression was defined as a subsequent diagnosis of invasive carcinoma, carcinoma in situ (including ductal carcinoma in situ [DCIS] or pleomorphic lobular carcinoma in situ), or high\u2010risk lesion (HRL), including atypical ductal hyperplasia (ADH). Descriptive statistics and univariate analysis were used to evaluate associations between clinicopathologic factors and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 185 patients, 49 (26.5%) underwent surgical excision and 136 (73.5%) were managed non\u2010operatively. Surgical pathology revealed 1 invasive carcinoma (2.0%), 5 DCIS (10.2%), and 4 HRL (8.2%). In the non\u2010surgical group, 3 patients (2.2%) subsequently developed invasive carcinoma; no DCIS or HRL developed over a median follow\u2010up of 37\u00a0months. Presence of a palpable mass was the only factor that predicted surgical management (OR 2.65, 95% CI 1.06\u20136.60,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.036); no other clinicopathologic or imaging features were associated with upgrade or progression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although the surgical cohort demonstrated a higher\u2010than\u2010expected upgrade rate, most upgrades consisted of DCIS or HRL, and progression among non\u2010surgically managed patients was rare after more than 3\u00a0years of follow\u2010up. These findings suggest that RS and CSL are rarely associated with clinically significant disease, supporting surveillance as an appropriate management strategy in contemporary practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70426","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:40:01Z","timestamp":1779108001000},"page":"1739-1747","source":"Crossref","is-referenced-by-count":0,"title":["Management of Radial Scars and Complex Sclerosing Lesions of the Breast: To Excise or Not to Excise?"],"prefix":"10.1002","volume":"50","author":[{"given":"Nicholas","family":"Zakem","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Addie","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Josey","sequence":"additional","affiliation":[{"name":"Breast Center McGill University Health Centre  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Florea","sequence":"additional","affiliation":[{"name":"Department of Pathology Jewish General Hospital  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ipshita","family":"Prakash","sequence":"additional","affiliation":[{"name":"Division of General Surgery McGill University Health Centre  Montreal Quebec Canada"},{"name":"Division of General Surgery Jewish General Hospital  Montreal Quebec Canada"},{"name":"Lady Davis Institute for Medical Research, Jewish General Hospital  Montreal Quebec Canada"},{"name":"Department of Surgery &amp; Oncology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of General Surgery McGill University Health Centre  Montreal Quebec Canada"},{"name":"Division of General Surgery Jewish General Hospital  Montreal Quebec Canada"},{"name":"Lady Davis Institute for Medical Research, Jewish General Hospital  Montreal Quebec Canada"},{"name":"Department of Surgery &amp; Oncology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3453-6960","authenticated-orcid":false,"given":"Sarkis","family":"Meterissian","sequence":"additional","affiliation":[{"name":"Breast Center McGill University Health Centre  Montreal Quebec Canada"},{"name":"Division of General Surgery McGill University Health Centre  Montreal Quebec Canada"},{"name":"Department of Surgery &amp; Oncology McGill University  Montreal Quebec 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