{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:25:43Z","timestamp":1786951543960,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100017682","name":"Construction Project of Fujian Province Minimally Invasive Medical Center","doi-asserted-by":"publisher","award":["[2017]171"],"award-info":[{"award-number":["[2017]171"]}],"id":[{"id":"10.13039\/501100017682","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Low rectal cancer poses unique surgical challenges due to its anatomy, complicating the balance between radical resection and functional preservation. Early\u2010onset low rectal cancer (EO\u2010LRC, &lt; 50\u00a0years) adds complexity: it has distinct, more aggressive biological\/clinical features but no age\u2010stratified surgical guidelines. Moreover, laparoscopic surgery's efficacy in EO\u2010LRC is controversial\u2014though non\u2010inferior in general low rectal cancer, EO\u2010LRC's aggressiveness may offset its benefits. This study aims to compare oncologic outcomes of laparoscopic versus open surgery in EO\u2010LRC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>In this post\u2010hoc analysis of the LASRE trial, the cohort included 240 EO\u2010LRC and 799 late\u2010onset low rectal cancer (LO\u2010LRC, \u2265 50\u00a0years) patients, and were randomly assigned to open or laparoscopic resection. Primary endpoints were 3\u2010year overall survival (OS) and disease\u2010free survival (DFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      EO\u2010LRC exhibited better ECOG performance status and lower ASA scores; however, they presented with more advanced disease and received more preoperative therapy. The operative time and blood loss were comparable. EO\u2010LRC patients had a higher proportion of pN2 stage and poorly differentiated tumors. The total mesorectal excision quality and negative margins were similar. The 3\u2010year OS (laparoscopic 91.3% vs. open 95.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.270) and DFS (laparoscopic 78.6% vs. open 76.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.657) were comparable between groups. Multivariate analysis identified preoperative therapy and pN classification as significant prognostic factors for DFS. No significant differences in oncologic outcomes were observed between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Laparoscopic TME provides non\u2010inferior oncologic control in EO\u2010LRC patients. The small EO\u2010LRC sample size necessitates cautious interpretation of findings, requiring validation in larger cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70450","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T04:52:33Z","timestamp":1781153553000},"page":"2229-2240","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Oncologic Outcomes of Laparoscopic versus Open Surgery for Early\u2010Onset Low Rectal Cancer: 3\u2010Year Results From the LASRE Trial"],"prefix":"10.1002","volume":"50","author":[{"given":"Yanwu","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery Fujian Medical University Union Hospital  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Fujian Medical University Union Hospital  Fuzhou Fujian 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