{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:25:44Z","timestamp":1786951544196,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thrombocytopenia is a common hematologic abnormality among critically ill patients and may reflect underlying sepsis or multi\u2010organ dysfunction. In low\u2010 and middle\u2010income countries (LMICs), constrained transfusion capacity and delayed presentation may amplify its prognostic significance. This study evaluated the association between thrombocytopenia and ICU mortality at a tertiary hospital in Malawi.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective analysis of patients admitted to the Kamuzu Central Hospital (KCH) Intensive Care Unit (ICU) in Lilongwe, Malawi, from 2016 to 2018. Platelet count was categorized as \u2264 50,000\/\u03bcL (severe thrombocytopenia), 50,000\u2013150,000\/\u03bcL (thrombocytopenia), and \u2265 150,000\/\u03bcL (normal). Bivariate and multivariable logistic regression analyses were performed to identify predictors of mortality. Bivariate analyses and multivariable logistic regression were used to identify factors associated with mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 498 patients, 95 (19.1%), 70 (14.1%), and 37 (7.4%) have mild, moderate, and severe thrombocytopenia, respectively. The overall incidence of critical illness thrombocytopenia is 40%. Overall ICU mortality was 51.2% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0255), with higher mortality among those with severe thrombocytopenia compared to normal platelet counts (70.3% vs. 50.7%). After adjustment for confounders, severe thrombocytopenia remained independently associated with mortality (OR 2.57, 95% CI 1.18\u20135.58,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Thrombocytopenia, particularly platelet counts \u2264 50,000\/\u03bcL, is independently associated with increased mortality among critically ill patients in resource\u2010limited ICUs. In contexts with limited transfusion and diagnostic capacity, platelet count may serve as a practical and accessible prognostic marker to identify high\u2010risk patients and guide early intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70473","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:26:16Z","timestamp":1782537976000},"page":"2265-2269","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and Outcomes of Thrombocytopenia at ICU\u00a0Admission Among Critically Ill Patients in a Resource\u2010Limited Setting"],"prefix":"10.1002","volume":"50","author":[{"given":"Sonam J.","family":"Shah","sequence":"first","affiliation":[{"name":"School of Medicine University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishita","family":"Chamarthi","sequence":"additional","affiliation":[{"name":"School of Medicine University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jotamu","family":"Gondwe","sequence":"additional","affiliation":[{"name":"Kamuzu Central Hospital  Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7332-4354","authenticated-orcid":false,"given":"Anthony","family":"Charles","sequence":"additional","affiliation":[{"name":"School of Medicine University of North Carolina  Chapel Hill North Carolina USA"},{"name":"Kamuzu Central Hospital  Lilongwe Malawi"},{"name":"Department of Surgery University of Vermont  Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000121433.61546.a0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0000000000003644"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2023.154293"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13699"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.20329"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/106002809502900901"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109343(90)90465\u2010p"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/1687\u20108426.145712"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2006.05.001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2991\/dsahmj.k.190617.002"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.15761\/VDT.1000132"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010129\u201011_Part_1\u2010199812010\u201000009"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2018.1500173"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjs.70473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/wjs.70473","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjs.70473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T06:59:51Z","timestamp":1786949991000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/wjs.70473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,26]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/wjs.70473"],"URL":"https:\/\/doi.org\/10.1002\/wjs.70473","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,26]]}}}