{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:25:42Z","timestamp":1786951542370,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Low skeletal muscle mass is associated with poor overall survival (OS) after gastrectomy in patients with gastric cancer, but it remains unclear whether this prognostic effect differs between men and women. This study aimed to clarify sex differences in the effect of low muscle mass on OS after gastrectomy for gastric cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included patients who underwent radical gastrectomy for pathological stage I\u2013III gastric cancer between 2010 and 2017. The skeletal muscle mass index (SMI) was calculated at the level of the third lumbar vertebra, and values lower than the Asian cutoff were defined as low. We compared OS as the primary outcome stratified by sex and muscle mass. Multivariate analysis was used to investigate the prognostic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median follow\u2010up duration was 66\u00a0months. Of the 653 male patients, 416 (63.7%) had a high\u2010SMI and 237 (36.3%) had a low\u2010SMI. Of the 382 female patients, 182 (47.6%) had a high\u2010SMI and 202 (52.4%) had a low\u2010SMI. Compared with the high\u2010SMI group, the low\u2010SMI group had significantly poorer OS in men (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), but not in women (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.177). Multivariate analyses showed that low\u2010SMI was an independent poor prognostic factor for OS in men (hazards ratio, 2.450; 95% confidence interval, 1.202\u20134.994;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.014) but not in women (hazards ratio, 1.417; 95% confidence interval, 0.584\u20133.438;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.441).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Low SMI was independently associated with worse OS after gastrectomy in patients with gastric cancer, with a significant association in men but not in women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70480","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:45:05Z","timestamp":1783421105000},"page":"2409-2420","source":"Crossref","is-referenced-by-count":0,"title":["Sex Differences in the Association Between Low Skeletal Muscle Mass and Overall Survival in Patients With Gastric Cancer After Gastrectomy: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"50","author":[{"given":"Ryota","family":"Matsui","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery The Cancer Institute Hospital of Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Department of Gastrointestinal Surgery\/Breast Surgery Graduate School of Medical Science Kanazawa University  Kanazawa City Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souya","family":"Nunobe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery The Cancer Institute Hospital of Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motonari","family":"Ri","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery The Cancer Institute Hospital of Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Makuuchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery The Cancer Institute Hospital of Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Department of Esophageal and Gastroenterological Surgery Juntendo University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2056-0721","authenticated-orcid":false,"given":"Tomoyuki","family":"Irino","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery The Cancer Institute Hospital of Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Hayami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery The Cancer Institute Hospital of Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery The Cancer Institute Hospital of Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery The Cancer Institute Hospital of Japanese Foundation for Cancer Research  Tokyo 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